Home > Academics > Academic Units > Departments > Biotechnology > Tapas Kumar Maiti
Visiting Professor
Biotechnology
LAB RESEARCH SUMMARY: Our laboratory works on isolation and characterization of anticancer and immunomodulatory biomolecules and tissue engineering matrices from natural sources. Currently, the focus of the lab is fabrication of in vivo-like organ models on microfluidic chips (called biochips) to study physiological phenomenon like vasculogenesis, autophagy and disease models for chronic myeloid leukemia and osteoarthritis. These models can be used to screen various drugs in a multiplexing mode, circumventing conventional mice experiments and to develop a therapeutic regime of the drug. Tissue Engineering : (i) Vascular Tissue Engineering ? Fabrication of vascular tissue constructs using modular tissue engineering approach using goat tendon collagen as base material, and developing a micro-scale platform for high throughput screening of antiangiogenic and anticarcinogenic drugs. (ii) Osteochondral Tissue Engineering - Developing an in vitro bio-mimetic tissue platform of human osteochondral complex. The platform will be used for understanding the consequences of biophysical and biochemical cues on degenerative changes in the cartilage and cartilage/bone interface and can be used as osteoarthritis drug screening platform. (iii) Liver Tissue Engineering ? Design and fabrication bio-artificial liver on a chip using dielectrophoresis based three-dimensional cell patterning in micro-confinements. This system may find application in high throughput screening of drugs/therapeutics related to tissue regeneration and lymphatic disorder. Biomicrofluidics : (i) Cancer stem cells and Leukaemia - Development of an in vivo-like microarchitecture on microfluidic platform to understand the complex dynamic biophysical interactions between hematopoietic or leukaemia stem cells and their niche. The platform will be used as a scheme to detect and target leukemia stem cells in clinical settings. (ii) Mechanobiology and Autophagy ? To understand, how different biophysical factors and stress acting on cancer cells, which elicit cellular responses like autophagy and how such response govern processes like cellular migration, invasion and survival.
Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia derived proteoglycans by I. Sarangi, D Ghosh, S K Bhutia, S Mallick and T.K.Maiti International Immunopharmacology 6 1287-1297 (2006)
Micro contact Printing of Concanavalin A and its effect on mammalian cell morphology by T. Das, S. K. Mallick, D. Paul, S. K. Bhutia, T. K. Bhattacharyya and T.K.Maiti Journal of Colloid and Interface Scienc 314 71-79 (2007)
Antiproliferative and immunostimulatory protein fraction from edible mushrooms by S. Maiti, S. K. Bhutia, S. K. Mallick, A.Kumar, N. Khadgi, Tapas K Maiti Environmental Toxicology and Pharmacology 26 187-191 (2008)
Traction Force Microscopy On-Chip(2008): Shear Deformation of Fibroblast Cells by T. Das, T. K. Maiti, S. Chakraborty Lab on chip 8 1308 - 1318 (2008)
Antitumor and proapoptotic effect of Abrus agglutinin derived peptide in Dalton's Lymphoma tumor model by S. K. Bhutia, S. K. Mallick, S. Maiti, T. K Maiti Chemico-Biological Interactions 174 11-18 (2008)
Abrus abrin derived peptides induce apoptosis by targeting mitochondria in HeLa cells. Cell Biology International by S. K. Bhutia, S. K. Mallick, T. K Maiti Cell Biology International 33 720-727 (2009)
Heteroglucan-dendrimer glycoconjugate: a modulated construct with augmented immune responses and signaling phenomena by K. Sanjana P. Devi, Birendra Behera, Banalata Sahoo, Tapas K. Maiti Biochimica et Biophysica acta - General Subjects 1840 2794-2805 (2014)
On-chip lectin microarray for glycoprofiling of different gastritis types and gastritic cance by Bibhas Roy, Gautam Chattopadhyay, Debasish Mishra, Tamal Das, Suman Chakraborty, Tapas K. Maiti Biomicrofluidics 8 - (2014)
Cell Penetrating Peptides from Agglutinin protein of Abrus precatorius facilitate the uptake of Imatinib Mesylate by Birendra Behera, Devdeep Mukherjee , Tarun Agarwal, Joyjyoti Das, Sudip K. Ghosh, Tapas K. Maiti Colloids and Surfaces B: Biointerfaces 140 169-175 (2016)
Institute Small Animal House IIT KHARAGPUR
Development of Indigenous Detection Tool for Entamoeba Histolytica from Stool Sample Ministry of Health and Family Welfare
Development of Infrastructure for Germ-Free/Gnotobiotic Mice for Screening of Psychobiotics Strains (SGDRI-2015) IIT KHARAGPUR
Understanding Vocalization Development Deficits in Mouse Models of Autism Spectrum Disorders-Role of Subplate Neurons (SGIGC-2015) IIT KHARAGPUR
Centre of excellence for training and research in Microfluidics IIT KHARAGPUR
Devdeep Mukherjee
Area of Research: Spatio-temporal regulation of cellular differentiation
Somnath Maji
Area of Research: Tissue engineering
Tanmoy Bagui
Area of Research: Systems Biology
Tarun Agarwal
Area of Research: Tissue Engineering
Ayan Chatterjee
Area of Research: Cancer Cell Reserach
Yuvarani M S
Area of Research: Neurobiology
