Home > Academics > Academic Units > Departments > Chemistry > Kiran Ramakant Gore
Assistant Professor Grade-I
Chemistry
Research Interests
Our lab work at the interface of organic synthesis and chemical biology. We are interested in the synthesis of chemically modified oligonucleotides (ASOs, siRNAs, aptamer, etc.) and testing their biochemical properties. We synthesize chemically modified oligonucleotides to improve stability, cellular uptake, and potency in therapeutic applications. Few projects are in the pipeline, such as synthesis and applications of fluorescent nucleosides to study nucleic acid interactions, targeted delivery of siRNAs, etc. We are also involved in the development of turn-on fluorescent probes for the detection of biologically important molecules such as cyanide, biological thiols, heavy metals, etc. In the area of synthetic chemistry, we are developing new methodologies in the synthesis of chemically modified nucleosides, developing optical probes, etc.
A Novel Green Florescent Protein Analog for Selective and Rapid Detection of H2S in Water as well as in Living Cells by Mittapelli L. L., Nawale G. N., Gholap S. P., Varghese O. P., Gore K. R. Sensors and actuators B: Chemical 298 126875-126882 (2019)
large Stokes shift fluorogen-activating RNA aptamer by Steinmetzger C., Palaniswamy N. , Gore K. R., Höbartner C. Chemistry-European Journal 25 1931-1935 (2019)
Journey of siRNA: Clinical Developments and Targeted Delivery by Nikam R. R., Gore K. R. Nucleic Acid Therapeutics 1 209-224 (2018)
Novel Silylated HBI Analog for Rapid, Selective, and Sensitive Detection of Cyanide in Water and Living Cells by Mirajkar A. L., Mittapelli L. L., Nawale G. N., Gore K. R. Sensors and actuators B: Chemical 265 257-263 (2018)
The N2-Furfural Deoxyguanosine (fdG) Adduct Does Not Alters The Structure of B-DNA by Ghodke P., Gore K. R., Harikrishna S. , Samanta B. , Kottur J. , Nair D. T., Pradeepkumar P. I. Journal of Organic Chemistry 81 502-511 (2016)
Unique Structural Features in DNA polymerase IV Enable Efficient Bypass of the N2 Adduct Induced by the Nitrofurazone Antibiotic by Kottur J., Sharma A. , Gore K. R., Narayan N. , Samanta B. , Pradeepkumar P. I., Nair D. T. Structure 23 56-67 (2015)
Design, Synthesis, Biophysical and Primer Extension Studies of Novel Acyclic Butyl Nucleic Acid (BuNA) by Kumar V., Gore K. R., Pradeepkumar P. I., Kesavan V. Organic and Biomolecular Chemistry 11 5853-5865 (2013)
Influence of 2 -Fluoro versus 2 -O-Methyl Substituent on the Sugar Puckering of 4 -C-Aminomethyl-uridine by Gore K. R., Harikrishna S. , Pradeepkumar P. I. Journal of Organic Chemistry 78 9956-9962 (2013)
Incorporation of 4'-C-Aminomethyl-2'-O-Methylthymidine into DNA by Thermophilic DNA Polymerases by Nawale G. N., Gore K. R., Höbartner C. , Pradeepkumar P. I. Chemical Communications 48 9619-9621 (2012)
Synthesis, Gene Silencing, and Molecular Modelling Studies of 4 -C-Aminomethyl-2 -O-Methyl-Modified Small Interfering RNAs by Gore K. R., Nawale G. N., Harikrishna S. , Chittoor V. , Pandey S. , Höbartner C. , Patankar S. , Pradeepkumar P. I. Journal of Organic Chemistry 77 3233-3245 (2012)
