A major area of our research is concerned with the physicochemical properties and self-assemblies of synthetic surfactants, especially chiral surfactants. With a wide range of techniques available it is natural that we cover a wide range of problems. My group is interested in how the molecular geometry affects the association properties of ionic surfactants and surfactant mixtures in aqueous and saline solutions. My group has developed some single-chain chiral surfactants that form vesicles at relatively low concentrations.
One of the areas my group currently focusing attention on is drug and gene delivery using stimuli-responsive (pH, temperature, etc.) vesicles and hydrogels. Our aim is to prepare stable unilamellar vesicles and hydrogels of amphiphilic molecules that can be used for drug/gene delivery, formulations of health-care products, and water pollution control. We have developed some responsive hydrogel formed by amino acid based chiral surfactants. My group has also discovered molecules that gel edible, as well as mineral oils.
In recent years, increasing environmental pressure to utilize safer, "greener" working practices has resulted in a dramatic expansion in the use of such water-soluble/dispersible systems in industrial processes. Water-soluble polymers that exhibit "smart" behavior (i.e. which have the ability to change their conformation in response to an external stimulus such as temperature or pH) are of particular interest as they can be used as injectable delivery systems. We have developed some pH- and redox-sensitive polymeric micelles and vesicles for delivery of anticancer drugs.
Since my group is dedicated to developing biodegradable and biocompatible drug delivery systems, a sizable part of our research involves synthesis and characterization of small molecules and polymers. Therefore, all chemists (Physical, Organic and Inorganic) are welcome to my group. I believe my group members get a complete training in Chemistry which enable them pursue independent research after the Ph.D. program.
Evaluation of zwitterionic polymersomes spontaneously formed by pH-sensitive and biocompatible PEG based random copolymers as drug delivery systems by P. Laskar, J. Dey, and S. K. Ghosh Colloids & Surfaces B: Biointerfaces 139 107-116 (2016)
Vesicle Formation by L-Cysteine-Derived Unconventional Single-Tailed Amphiphiles in Water: A Fluorescence, Microscopy and Calorimetric Investigation. by R. Ghosh and J. Dey Langmuir 30 13516-13524 (2014)
Amyloid fibril formation by pepsin in neutral pH at room temperature. by S. Ghosh, S. Dolai, J. Dey Soft Matter 9 11457-11460 (2013)
Can Molecules with Anionic Head and Poly(ethylene glycol) methyl ether Tail Self-assemble in Water? A Surface tension, Fluorescence Probe, Light Scattering, and Transmission Electron Microscopic Investigation. by J. Dey and S. Shrivastava Soft Matter 8 1305-1308 (2012)
Water-Induced Physical Gelation of Organic Solvents by N-(n-Alkyl-carbamoyl)-L-alanine Amphiphiles. by A. Pal, and J. Dey Langmuir 27 3401-3408 (2011)
A Supramolecular Hydrogel that Responds to Biologically Relevant Stimuli. by D. Khatua, R. Maiti, and J. Dey Chem. Com. 4903-4905 (2006)
Microviscosity of Bilayer Membranes of Some N-Acyl Amino Acid Surfactants Determined by Fluorescence Probe Method. by S. Roy, A. Mohanty and J. Dey Chem. Phys. Lett. 414 23-27 (2005)
Vesicles as pseudostationary phase for enantiomer separation by capillary electrophoresis. by A. Mohanty and J. Dey , J. Chromatogr. A 1070 185-192 (2005)
A Giant Vesicle Forming Single Tailed Chiral Surfactant for Enantioseparation by Micellar Electrokinetic Chromatography. by A. Mohanty and J. Dey Chem. Com. 1384-1385 (2003)
Equilibrium Constants for Dehydration of Water Adducts of Aromatic Carbon-Carbon Double Bonds. by J. Dey, A.C. O Donoghue and R. A. More O Ferrall J. Am. Chem. Soc. 124 8561-8574 (2002)
Area of Research: Molecular Self-Assembly and Drug Delivery