Home > Academics > Academic Units > Departments > Chemistry > Kiran Ramakant Gore
Assistant Professor Grade-I
Chemistry
Research Interests
Our lab work at the interface of organic synthesis and chemical biology. We are interested in the synthesis of chemically modified oligonucleotides (ASOs, siRNAs, aptamer, etc.) and testing their biochemical properties. We synthesize chemically modified oligonucleotides to improve stability, cellular uptake, and potency in therapeutic applications. Few projects are in the pipeline, such as synthesis and applications of fluorescent nucleosides to study nucleic acid interactions, targeted delivery of siRNAs, etc. We are also involved in the development of turn-on fluorescent probes for the detection of biologically important molecules such as cyanide, biological thiols, heavy metals, etc. In the area of synthetic chemistry, we are developing new methodologies in the synthesis of chemically modified nucleosides, developing optical probes, etc.
Journey of siRNA: Clinical Developments and Targeted Delivery by Nikam R. R., Gore K. R. Nucleic Acid Therapeutics 1 209-224 (2018)
Novel Silylated HBI Analog for Rapid, Selective, and Sensitive Detection of Cyanide in Water and Living Cells by Mirajkar A. L., Mittapelli L. L., Nawale G. N., Gore K. R. Sensors and actuators B: Chemical 265 257-263 (2018)
The N2-Furfural Deoxyguanosine (fdG) Adduct Does Not Alters The Structure of B-DNA by Ghodke P., Gore K. R., Harikrishna S. , Samanta B. , Kottur J. , Nair D. T., Pradeepkumar P. I. Journal of Organic Chemistry 81 502-511 (2016)
Unique Structural Features in DNA polymerase IV Enable Efficient Bypass of the N2 Adduct Induced by the Nitrofurazone Antibiotic by Kottur J., Sharma A. , Gore K. R., Narayan N. , Samanta B. , Pradeepkumar P. I., Nair D. T. Structure 23 56-67 (2015)
Design, Synthesis, Biophysical and Primer Extension Studies of Novel Acyclic Butyl Nucleic Acid (BuNA) by Kumar V., Gore K. R., Pradeepkumar P. I., Kesavan V. Organic and Biomolecular Chemistry 11 5853-5865 (2013)
Influence of 2 -Fluoro versus 2 -O-Methyl Substituent on the Sugar Puckering of 4 -C-Aminomethyl-uridine by Gore K. R., Harikrishna S. , Pradeepkumar P. I. Journal of Organic Chemistry 78 9956-9962 (2013)
Incorporation of 4'-C-Aminomethyl-2'-O-Methylthymidine into DNA by Thermophilic DNA Polymerases by Nawale G. N., Gore K. R., Höbartner C. , Pradeepkumar P. I. Chemical Communications 48 9619-9621 (2012)
Synthesis, Gene Silencing, and Molecular Modelling Studies of 4 -C-Aminomethyl-2 -O-Methyl-Modified Small Interfering RNAs by Gore K. R., Nawale G. N., Harikrishna S. , Chittoor V. , Pandey S. , Höbartner C. , Patankar S. , Pradeepkumar P. I. Journal of Organic Chemistry 77 3233-3245 (2012)
Synthesis of 4-C-Aminomethyl-2-O-Methoxyethyl Pyrimidines Modified siRNAs and Study Their Duplex Stability, Nuclease Resistance, and RNAi Activity for Potential Therapeutic Applications Science and Engineering Research Board (SERB)
Synthesis, Biochemical and Biophysical Evaluation of Novel 4-C-Aminomethyl-2-O-Propyle and 2-O-Propyl Pyrimidines Modified Small Interfering RNAs ISIRD, SRIC
Synthesis and In Vivo Applications of 4-C-Methylhistaminyl Uridine and Cytidine Modified Small Interfering RNAs Department of Science and Technology
Dola Dev
Area of Research: Bio organic Chemistry
Sumit Gangopadhyay
Area of Research: Bio organic Chemistry
Ritwika Dey
Area of Research: Bioorganic Chemistry
Gourav Das
Area of Research: Bioorganic Chemistry
