Home > Academics > Academic Units > Departments > Chemistry > Swagata Dasgupta
Professor
Chemistry
Protein aggregation studies: Aggregation studies currently underway involve human serum albumin, lysozyme and the amyloid peptide fragment Ab25-35. Effects of a static electric field on the disruption of fibrils have been reported. Work with polyphenols and surfactants and their effects on the fibrillation process of proteins are in progress. The disruption of the fibrillation of amyloid fibrils, the hallmark of neurodegenerative diseases in the presence of external additives is currently underway.
Studies with eye lens proteins: Modified γ-crystallin (HGCc) from the discarded cataractous emulsion of patients has been isolated and characterized for modifications during cataract formation. Studies showed that the major polyphenol present in green tea, EGCG was able to prevent tryptophan oxidation of the cataractous ocular lens human γ-crystallin in presence of H2O2. The discarded mass is being used to prepare protein nanoparticles and films for applications in drug delivery, wound healing etc. A patent has been awarded for the use of this novel protein source in the preparation of the nanoparticles.
Protein ligand binding: Studies with ribonucleases such as angiogenin, a potent inducer of blood vessel formation, indicated that the process of angiogenesis, the capacity to form blood vessels, was inhibited by polyphenols present in green tea. The polyphenols were also shown to behave as noncompetitive inhibitors of Ribonuclease A. Other inhibitors of the proteins are being developed in collaboration. The effects of oxidative stress on the proteins and methods to combat them are in progress.
Enhancement of angiogenin inhibition by polyphenol capped gold nanoparticles by Panda A., Karhadkar S. , Acharya B. , Banerjee A. , De S. , Dasgupta S. Biopolymers - (2021)
Positional preferences in flavonoids for inhibition of ribonuclease A: Where -OH where? by Tripathy D.R., Panda A., Dinda A.K., Dasgupta S. Proteins: Structure, Function and Bioinformatics 89 577-587 (2021)
Biodegradable protein films from gallic acid and the cataractous eye protein isolate. by Parveen S., Chaudhury P. , Dasmahaptra U. , Dasgupta S. International Journal of Biological Macromolecules - (Accepted/In-Press)
Tuning the mechanical and physicochemical properties of cross-linked protein films. by Parveen S., Chaudhury S. , Dasgupta S. Biopolymers - (Accepted/In-Press)
Preparation, characterization and in vitro release study of curcumin loaded cataractous eye protein isolate films. by Parveen S., Ghosh P. , Mitra A. , Gupta S. , Dasgupta S. Emergent Materials - (Accepted/In-Press)
PREPARATION OF NANOPARTICLES DERIVED FROM CATARACTOUS EYE PROTEIN ISOLATE by Dasgupta S., Chaudhury S. , Parveen S. - (2021)
Design of Configuration-Restricted Triazolylated -DRibofuranosides: A Unique Family of Crescent-Shaped RNase A Inhibitors. by Das A., Dasgupta S. , Pathak T. Org. Biomol. Chem 18 6340-6356 (2020)
Biodegradable protein films from gallic acid and the cataractous eye protein isolate by Parveen S., Chaudhury P., Dasmahapatra U., Dasgupta S. International Journal of Biological Macromolecules 139 12-20 (2019)
Effect of Silica Nanoparticles on the Amyloid Fibrillation of Lysozyme by Konar M., Mathew A. , Dasgupta S. ACS Omega 4 1015-1026 (2019)
Flavonoid loaded nanoparticles as an effective measure to combat oxidative stress in Ribonuclease A by Roy P., Parveen S. , Ghosh P. , Ghatak K. , Dasgupta S. Biochimie 162 185-197 (2019)
The Impact of Steroidal and Non-Steroidal Inhibitors on Aromatase: Significance on Estrogen-dependent Disease in Postmenopausal Women INDIAN COUNCIL OF MEDICAL RESEARCH (ICMR)
Studying the Effect of Actin Targeted Drugs on the Actin Binding Domain of Beta-Spectrin Department of Science and Technology (DST)
Scheme for Promotion of Academic and Research Collaboration (SPARC) - IIT Kharagpur as a Nodal Institute MHRD
Centre of excellence for training and research in Microfluidics IIT KHARAGPUR
Direct-To-Home (DTH) SWAYAM Prabha: Channel 11 (Chemical Engg. & Sciences) MHRD, Department of Higher Education, NMEICT, New Delhi
Ashrukana Das
Area of Research: Inhibition of ribonucleases with synthetic carbohydrates
Pampa Mondal
Area of Research: Inhibition of ribonucleases with synthetic nucleosides
Atashi Panda
Area of Research: Protein Chemistry
Prasun Chowdhury
Area of Research: Protein Chemistry
Krishna Halder
Area of Research: Protein Chemistry
Sreshtha Chaki
Area of Research: Protein Chemistry
Megh Mondal
Area of Research: Protein Chemistry and interactions
Goutam Nayak
Area of Research: Protein Chemistry
Atri Sen
Area of Research: Protein Chemistry
Kabira Sabnam
Area of Research: Protein Chemistry
Tridib Samanta
Area of Research: Protein Chemistry
