Home > Academics > Academic Units > Departments > Chemistry > Swagata Dasgupta
Professor
Chemistry
Protein aggregation studies: Aggregation studies currently underway are involving human serum albumin, lysozyme and the amyloid peptide fragment Ab25-35. Effects of a static electric field on the disruption of fibrils have been reported. Work with polyphenols and surfactants on the fibrillation of proteins have been initiated in order to study the amyloid fibrils, the hallmark of neurodegenerative diseases.
Studies with the eye lens proteins: Modified γ-crystallin (HGCc) from the discarded cataractous emulsion of patients was isolated and characterized. Studies showed that the major polyphenol present in green tea, EGCG was able to prevent tryptophan oxidation of cataractous ocular lens human γ-crystallin in presence of H2O2. The discarded mass is being used to prepare protein nanoparticles and films for applications in drug delivery, wound healing etc.
Protein ligand binding: Studies with ribonucleases such as angiogenin, indicated that the process of angiogenesis, the capacity to form blood vessels, was inhibited by polyphenols present in green tea. The polyphenols behave as noncompetitive inhibitors of Ribonuclease A. Other inhibitors of the proteins are being developed in addition to an investigation into the effects of oxidative stress on the protein.
Scheme for Promotion of Academic and Research Collaboration (SPARC) - IIT Kharagpur as a Nodal Institute MHRD
Scheme for Promotion of Academic and Research Collaboration (SPARC) - Projects of IIT-KGP MHRD
Poly Lactic-Co-Glycolic Acid (PLGA) Based Nanoparticles for Delivery of Polyphenols and Effect of Human Serum Albumin (HSA) on their Release Property and Antioxidant Property Council of Scientific and Industrial Research, Extramural Research Division
Direct-To-Home (DTH) SWAYAM Prabha MHRD, Department of Higher Education, NMEICT, New Delhi
Centre of excellence for training and research in Microfluidics IIT KHARAGPUR
Ashrukana Das
Area of Research: Inhibition of ribonucleases with synthetic carbohydrates
Pampa Mondal
Area of Research: Inhibition of ribonucleases with synthetic nucleosides
Atashi Panda
Area of Research: Protein Chemistry
Anang Kumar Singh
Area of Research: Nano-Bio Science
Hemant Kumar Srivastava
Area of Research: Neurobiology
Prasun Chowdhury
Area of Research: Protein Chemistry
Krishna Halder
Area of Research: Protein Chemistry
Sreshtha Chaki
Area of Research: Protein Chemistry
Megh Mondal
Area of Research: Protein Chemistry and interactions
Goutam Nayak
Area of Research: Protein Chemistry
