Home > Academics > Academic Units > Departments > Chemistry > Swagata Dasgupta
Professor
Chemistry
The major contribution to research in protein chemistry has been in the areas of protein ligand binding, protein isolation and characterization and protein structure analyses at IIT Kharagpur. Over the years this laboratory has become as an active center of research with generous support from funding agencies. Many research projects including many collaborative projects have been undertaken in interdisciplinary areas. Till date 17 Ph.D. students have been guided. The unique feature of the work is the blend of experimental protein chemistry with in-depth structural analysis.
The major areas are:
Protein aggregation studies: Aggregation studies currently underway are involving human serum albumin, lysozyme and ribonuclease A. We have established that Cu(II) plays a vital role in the fibrillation process of human serum albumin and lysozyme. Effects of a static electric field on the disruption of fibrils have been reported recently.
Isolation and characterization of modified γ-crystallin (HGCc): Modified γ-crystallin (HGCc) has been isolated from the discarded cataractous emulsion of patients. Briefly, pooled lens emulsions were centrifuged followed by lyophilization of the supernatant and subsequent dialysis. The dialyzed emulsion was purified by gel filtration and characterized for further study.
Protein ligand binding: Novel studies with angiogenin indicated that the process of angiogenesis, the capacity to form blood vessels, was inhibited by polyphenols present in green tea. The polyphenols behave as noncompetitive inhibitors of Ribonuclease A. It was found that the copper complexes formed with the two gallate containing polyphenols were better inhibitors of the ribonucleolytic activity than the polyphenols.
Scheme for Promotion of Academic and Research Collaboration (SPARC) - Projects of IIT-KGP MHRD
Scheme for Promotion of Academic and Research Collaboration (SPARC) - IIT Kharagpur as a Nodal Institute MHRD
Poly Lactic-Co-Glycolic Acid (PLGA) Based Nanoparticles for Delivery of Polyphenols and Effect of Human Serum Albumin (HSA) on their Release Property and Antioxidant Property Council of Scientific and Industrial Research, Extramural Research Division
Scheme for Promotion of Academic and Research Collaboration (SPARC) MHRD
Femtosecond laser facility to investigate confined media, biological assemblies. room temperature ionic liquids and nano-materials Science and Engineering Research Board (SERB)
Direct-To-Home (DTH) SWAYAM Prabha MHRD, Department of Higher Education, NMEICT, New Delhi
Centre of excellence for training and research in Microfluidics IIT KHARAGPUR
Anupam Apoorva
Area of Research: Secondary metabolites research
Pritam Roy
Area of Research: Protein Chemistry
Sultana Parveen
Area of Research: Protein isolation and characterization
Ashrukana Das
Area of Research: Inhibition of ribonucleases with synthetic carbohydrates
Pampa Mondal
Area of Research: Inhibition of ribonucleases with synthetic nucleosides
Atashi Panda
Area of Research: Protein Chemistry
Anang Kumar Singh
Area of Research: Nano-Bio Science
Hemant Kumar Srivastava
Area of Research: Neurobiology
Prasun Chowdhury
Area of Research: Protein Chemistry
Krishna Halder
Area of Research: Protein Chemistry
Sreshtha Chaki
Area of Research: Protein Chemistry
