IITKGP

Swagata Dasgupta

Professor

Chemistry

+91-3222-283306

swagata@chem.iitkgp.ac.in

Research Areas

  • Protein protein interactions
  • Protein aggregation Studies
  • Protein Chemistry
  • Protein - small molecule interactions
Protein aggregation studies: Aggregation studies currently underway involve human serum albumin, lysozyme and the amyloid peptide fragment Ab25-35. Effects of a static electric field on the disruption of fibrils have been reported. Work with polyphenols and surfactants and their effects on the fibrillation process of proteins are in progress. The disruption of the fibrillation of amyloid fibrils, the hallmark of neurodegenerative diseases in the presence of external additives is currently underway.
 
Studies with eye lens proteins: Modified γ-crystallin (HGCc) from the discarded cataractous emulsion of patients has been isolated and characterized for modifications during cataract formation. Studies showed that the major polyphenol present in green tea, EGCG was able to prevent tryptophan oxidation of the cataractous ocular lens human γ-crystallin in presence of H2O2. The discarded mass is being used to prepare protein nanoparticles and films for applications in drug delivery, wound healing etc. A patent has been awarded for the use of this novel protein source in the preparation of the nanoparticles.
 
Protein ligand binding: Studies with ribonucleases such as angiogenin, a potent inducer of blood vessel formation, indicated that the process of angiogenesis, the capacity to form blood vessels, was inhibited by polyphenols present in green tea. The polyphenols were also shown to behave as noncompetitive inhibitors of Ribonuclease A. Other inhibitors of the proteins are being developed in collaboration. The effects of oxidative stress on the proteins and methods to combat them are in progress.
 
  • Flavonoid loaded nanoparticles as an effective measure to combat oxidative stress in Ribonuclease A Roy P., Parveen S. , Ghosh P. , Ghatak K. , Dasgupta S. By Biochimie 162 185-197 (2019)
  • Positional preferences in flavonoids for inhibition of ribonuclease A: Where -OH where? Tripathy D.R., Panda A., Dinda A.K., Dasgupta S. By Proteins: Structure, Function and Bioinformatics 89 577-587 (2021)
  • Tuning the mechanical and physicochemical properties of cross-linked protein films. Parveen S., Chaudhury S. , Dasgupta S. By Biopolymers - (Accepted/In-Press)
  • PREPARATION OF NANOPARTICLES DERIVED FROM CATARACTOUS EYE PROTEIN ISOLATE Dasgupta S., Chaudhury S. , Parveen S. By - (2021)
  • Design of Configuration-Restricted Triazolylated -DRibofuranosides: A Unique Family of Crescent-Shaped RNase A Inhibitors. Das A., Dasgupta S. , Pathak T. By Org. Biomol. Chem 18 6340-6356 (2020)
  • Biodegradable protein films from gallic acid and the cataractous eye protein isolate Parveen S., Chaudhury P., Dasmahapatra U., Dasgupta S. By International Journal of Biological Macromolecules 139 12-20 (2019)
  • Effect of Silica Nanoparticles on the Amyloid Fibrillation of Lysozyme Konar M., Mathew A. , Dasgupta S. By ACS Omega 4 1015-1026 (2019)

Principal Investigator

  • Densely Functionalized Divinyl Sulfones- Synthesis Reactions and Applications in Biology and Material Science
  • Glycation of proteins to produce advanced glycation end products and find suitable conditions
  • Targeting the Active Site of Aromatase: Chemical Logic Based Design of Potential Anticancer Steroidal and Non-Sreroidal Inhibitors

Ph. D. Students

Atri Sen

Area of Research: Protein Chemistry

B Madhurima

Area of Research: Nano-Bio Science

Goutam Nayak

Area of Research: Protein Chemistry

Kabira Sabnam

Area of Research: Protein Chemistry

Krishna Halder

Area of Research: Protein Chemistry

Krishnananda C P

Area of Research: Nano-Bio Science

Pampa Mondal

Area of Research: Inhibition of ribonucleases with synthetic nucleosides

Piyasi Garai

Area of Research: Computer Simulation Studies of Proteins

Prasun Chowdhury

Area of Research: Protein Chemistry

Rashmita Pan

Area of Research: biologically relevant triazoles

Sreshtha Chaki

Area of Research: Protein Chemistry

Sujan Santra

Area of Research: Protein Chemistry

Tridib Samanta

Area of Research: Protein Chemistry