Amit Ghosh

Ph.D., IISc Bangalore

Associate Professor

Energy Science and Engineering



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  • Assistant Warden, Rajendra Prasad Hall

Research Areas

  • Modelling and simulation
  • 13C Metabolic Flux Analysis
  • Metabolic Engineering: Synthetic Biology
  • Multi-Omics Systems Biology
  • Computer Simulation of Biomolecules
  • Bioenergy
Rising costs and a depleting supply of oil, as well as environmental concerns, have led to strong interest in renewable fuels and chemicals. In the last decade, there was considerable interest for microbial production of biofuels by metabolic engineering approach as an attractive alternative to transportation fuels. 

Recent advancements of synthetic biology have led to the further development of genetic engineering of microorganism, which has been great motivation for developing strategy for microbial production of biofuels. Rational design of metabolism is very important for production of biofuels. In silico prediction of metabolic flux distribution of the metabolic pathways have enabled us to decide the time consuming steps in metabolic engineering.

In recent years significant efforts have been made to engineer microorganisms to produce bioethanol, higher chain alcohols, fatty acids and isoprenoid based biodiesel. Metabolic engineering involves improvement of biofuels formation through the modification of specific genes or addition of new genes involved in biochemical reactions with the use of recombinant DNA technology. System-level approach to analyze and engineer metabolism based on flux distributions obtained from metabolomics and 13C metabolic flux analysis have been extensively used by our group to produce biofuels in Escherichia coli and yeast. 
  • Understanding the conformational change and inhibition of hyperthermophilic GH10 xylanase in ionic liquid Manna B., Ghosh A. By Journal of Molecular Liquids 332 115875- (2021)
  • Recent Advances in Systems and Synthetic Biology Approaches for Developing Novel Cell-factories in Non-Conventional Yeasts Patra P., Das M. , Kundu P. , Ghosh A. By Biotechnology Advances 47 107695- (2021)
  • Molecular Insight into glucose induced conformational change to investigate uncompetitive inhibition of GH1 beta-glucosidase Manna B., Ghosh A. By ACS Sustainable Chemistry & Engineering 9 1613-1624 (2021)
  • Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS Cov2 infection Nanda P., Ghosh A. By PLoS Computational Biology 17 e10088- (2021)
  • Understanding the Dissolution of Softwood Lignin in Ionic Liquid and Water Mixed Solvents Manna B., Ghosh A. By International Journal of Biological Macromolecules 182 402-412 (2021)
  • Recent advancements in the ionic liquid mediated lignin valorization for the production of renewable materials and value-added chemicals Radhakrishnan R., Patra P. , Das M. , Ghosh A. By Renewable and Sustainable Energy Reviews 149 111368- (2021)
  • Reconstruction and analysis of genome-scale metabolic model of weak Crabtree positive yeast Lachancea kluyveri Nanda P., Patra P. , Das M. , Ghosh A. By Scientific Reports 10: 16314- (2020)
  • Reconstruction and analysis of genome-scale metabolic model of weak Crabtree positive yeast Lachancea kluyveri Nanda P., Patra P. , Das M. , Ghosh A. By Scientific Reports 10: 16314- (2020)
  • A review on co-culturing of microalgae: A greener strategy towards sustainable biofuels production Ray A., Nayak M. , Ghosh A. By Science of The Total Environment 802 149765- (2022)
  • Solvent Induced Conformational Changes for the Altered Activity of Laccase: A Molecular Dynamics Study Radhakrishnan R., Manna B. , Ghosh A. By Journal of Hazardous Materials 423 127123- (2022)

Principal Investigator

  • CRISPR/Ca9 mediated genome engineering in industrially relevant non-conventional yeast Kluyveromyces marxianus for enhanced fatty alcohol production
  • Development of Genome Engineering Platform in Industrially Relevant Yeast, Lachancea Kluyveri for Improved Production of Fatty-acid Derived Biofuels and Chemicals

Co-Principal Investigator

  • An Integrated Experimental Vis-a-Vis In -Silico Approach for System-Level Understanding of CO2 Fixation Abilities of Chemoautotrophic Microbial Communities Derived from Deep Subsurface Rocks for their Potential Application In Third Generation Biorefineries Science and Engineering Research Board (SERB)
  • Understanding Structure Function and Evolution of Regulatory Networks with a Special Emphasis on Human Diseases-BIC at Department of Biotechnology, IIT-Kharagpur DBT, NEW DELHI

Ph. D. Students

Ayusmita Ray

Area of Research: Metabolic Engineering

Gourab Bhattacharje

Area of Research: Molecular dynamics and simulation of protein

Manali Das

Area of Research: Metabolic Engineering

Nidhi Patawari

Area of Research: Metabolic Engineering

Pradipta Patra

Area of Research: Metabolic Engineering

Pritam Kundu

Area of Research: BioEnergy

R Som Dutt

Area of Research: Microbial Production of Biofules

Rokesh R

Area of Research: Metabolic Engineering

Romit Mitra

Area of Research: Process and Product Development

Ruma Shankaran

Area of Research: Microbial Production of Biofuels

Satyajit Beura

Area of Research: Computational Biology

Sayan Saha Roy

Area of Research: Computer simulation of Bioenergy Systems

Suman Mondal

Area of Research: Metagenomics