Home > Academics > Academic Units > Schools > School of Medical Science and Technology > Budhaditya Mukherjee
Assistant Professor Grade-I
School of Medical Science and Technology
We are new group focusing on different aspects of infectious intracellular protozoan pathogens using Leishmania, Toxoplasma and Plasmodium as model system. My research has always focused on different immunological and cellular aspects of parasite biology, that enables these intracellular pathogens to survive within the hostile host enviornment. My scholarship has rendered around theories and methods of protozoan parasitic diseases with applications to clinical importance. We have contributed significantly in the field of drug resistance leishmaniasis one of the major emerging problem for India with new cases reported every year. For a better understanding of protozoan mediated infectious disease I started working on Plasmodium and Toxoplasma causative agents of Malaria & Toxoplasmosis as an EMBO-Post-doctoral fellow. My post-doctoral scholarship primarily articulate in successfully characterized key factors involved in establishing successful infection and dissemination of apicomplexan parasites into or out of the host. During this peroid I also managed a collaborative project with industrial partner UCB Pharma S.A and Medicines for Malaria Venture (MMV) to design biochemical assays for therapeutic development.
My research interest is interdisciplinary in nature, and our lab want to explore the possibility to establish a potent CRISPR-Cas9 based genome editing techniques in protozoan biology, which in turn could be implemented in characterization of key components of disease pathogenesis & intra/inter species-transmission of these intracellular pathogens. Another focus of the lab would be to develop biochemical assays for activity-based protein profiling to study parasite biology with a particular view of developing them with potential translational value for pharma industries. This should also serve as the base to challenge the existing problem of drug resistance and absence of vaccine, and help in designing of novel drug targets against these pathogens which currently is affecting a huge part of population each year.
Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases by Mukherjee B., Tessaro F. , Vahokoski J. , Kursula I. , Marq J. , Scapozza L. , Soldati-favre D. EMBO J 37(7) 98047-98062 (2018)
A multi-stage antimalarial targets the plasmepsins IX and X essential for invasion and egress by Pino P., Caldelari R. , Mukherjee B. , Vahokoski J. , Klages N. , Maco B. , Collins C. ., Blackman M. J., Kursula I. , Heussler V. , Brochet M. , Soldati-favre D. Science 358(6362) 522-528 (2017)
A drugable secretory protein maturase of Toxoplasma essential for invasion and egress by Dogga S. K., Mukherjee B. , Jacot D. , Malino L. , Hammoudi P. , Hartkoorn R. , Hell A. , Soldat-favre D. Elife 6 27480- (2017)
Antimony-Resistant Leishmania donovani Exploits miR-466i To Deactivate Host MyD88 for Regulating IL-10/IL-12 Levels during Early Hours of Infection by Mukherjee B., Paul J. , Mukherjee S. , Mukhopadhyay R. , Das S. , Naskar K. , Dujardin J. , Roy S. J. Immunol 195(6) 2731--2742 (2015)
Imipramine exploits Histone deacetylase 11 to increase IL-12/IL-10 ratio in macrophages infected with antimony resistant Leishmania donovani and clears organ parasite in experimental infection by Mukherjee S., Mukherjee B. , Mukhopadhyay R. , Naskar K. , Dujardin J. , Roy S. J. Immunol 193(8) 4083-4094 (2014)
Antimony resistant Leishmania donovani upregulates IL-10 to overexpress host multi drug resistant protein1 by Mukherjee B., Mukhopadhyay R. , Bannerjee B. , Chowdhury S. , Naskar K. , Allam U. , Chakravortty D. , Sundar S. , Dujardin J. , Roy S. Proc Natl Acad Sci U S A 110(7) 575-582 (2013)
Imipramine is an Orally Active Drug against Both Antimony Sensitive and Antimony Resistant Leishmania donovani Clinical Isolates in Experimental Infection by Mukherjee S., Mukherjee B. , Mukhopadhyay R. , Naskar K. , Dujardin J. , Das A. , Roy S. PLoS Negl Trop Dis 6(12) 1987- (2012)
The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice by Chowdhury S., Mukherjee T. , Mukhopadhyay R. , Mukherjee B. , Sengupta S. , Chattopadhyay S. , Jaisankar P. , Roy S. , Majumder H. EMBO Mol Med 4(10) 1126-1143 (2012)
Characterisation of antimony-resistant Leishmania donovani isolates: biochemical and biophysical studies and interaction with host cells by Mukhopadhyay R., Mukherjee S. , Mukherjee B. , Naskar K. , Mondal D. , Decuypere S. , Ostyn B. , Prajapati V. , Sundar S. , Dujardin J. , Roy S. Int J Parasitol 41(13-14) 1311-1321 (2011)
Production of SARS-CoV-2 c-DNA Library with Specific Genome Architecture of Indian Isolates for Subsequent Development of Centralized In-house Repository of Recombinant Antigen and Antibody for COVID-19 Related Research SRIC, IIT KHARAGPUR
Identification and Characterization of Proteins Involved in Transmission Machinery of Protozoan Pathogens ISIRD, SRIC
Shreya Banerjee
Area of Research: Cancer Biology
Supratim Pradhan
Area of Research: Infectious disease and immunology
Souradeepa Ghosh
Area of Research: Infectious disease and immunology
Rishika Jana
Area of Research: Biochemistry of Leishmania parasite
Snehlata
Area of Research: Infectious disease and immunology
Shatarupa Bhattacharya
Area of Research: Application of molecular biology approaches for disease management
