We're new and evolving group, working on the areas of cell and molecular biology, medicine and genomics.
Work is related to long-standing and current problems in:
- Molecular cardiology and vascular biology (Key words: heart failure, inflammation & atherosclerosis, apoptosis & novel modes of cell death, cardiac remodeling, regeneration, immunobiology of heart and vessels, non-coding RNAs) This involves from in vitro to in vivo modeling of heart related diseases. With the use of various primary cells and cell lines, genetically modified mice and surgery, we induce diseases & pathologically similar conditions to study cardiovascular problems at cellular level.
- Developmental biology (cardiac and vascular development during embryogenesis) With timed mating protocols and by using genetically modified mice, our focus is to study genes in cardiac development and diseases.
BRCA1 is an essential regulator of heart function and survival following myocardial infarction by Shukla, P.C*., Singh, K.K*., Quan, A., Al-Omran, M. et. al. Nature Communication 2 - (2011)
Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction by Hilfiker-Kleiner, D., Shukla, P.C., Klein, G., Fischer, P., Schaefer, A., Stapel, B., Hoch, M., Müller, W., Scherr, M.,Theilmeier, G., Ernst, M., Hilfiker, A., Drexler, H. Circulation 122 (2) - (2010)
The forkhead transcription factor Foxo3 negatively regulates natural killer cell function and viral clearance in myocarditis by Loebel M., Luise Holzhauser L. , Hartwig J. A., Shukla P. C., Savvatis K. , Janke A. , Gast M. , Escher F. , Becker S. C., Bauer S. , Stroux A. , Beling A. , Kespohl M. , Pinkert S. , Fechner H. , Kuehl U. , Lassner D. , Poller W. , Schultheiss H. , Zeller T. , Blankenberg S. , Papageorgiou A. , Heymans S. , Landmesser U. , Scheibenbogen C. , Skurk C. European Heart Journal 1-12 (Accepted/In-Press)
Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 regulate endothelial cell calcium stores and angiogenic function as well as promotes ischemic blood flow recovery by Thompson, M.D., Mei, Y., Weisbrod, R.M., Silver, M., Shukla, P.C., Bolotina, V.M., Cohen, R.A., Tong, X. Journal of Biological Chemistry 289 (29) - (2014)
BRCA1 is a Novel Target to Improve Endothelial Dysfunction and Retard Atherosclerosis by *Singh, K.K., *Shukla, P.C., Quan, A., Al-Omran, M., Lovren, F., Pan, Y., Brezden-Masley, C., Ingram, A.J., Stanford, W.L., Teoh, H., Verma, S. Journal of Thoracic and Cardiovascular Surgery 146 (4) - (2013)
Regulating cardiac energy metabolism and bioenergetics by targeting the DNA damage repair protein BRCA1 by *Singh, K.K., *Shukla, P.C., *Yanagawa, B., Quan, A., Lovren, F, Pan, Y., Wagg, C. S., Teoh, H., Lopaschuk, G. D., Verma, S. Journal of Thoracic and Cardiovascular Surgery 146 (3) - (2013)
BRCA2 deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure by *Singh, K.K., *Shukla, P.C., Quan, A., Desjardins, J-F., Lovren, F., Pan, Y., Garg, V., Gosal, S., Garg, A., Szmitko, P.E., Schneider, M.D., et. al. Journal of Biological Chemistry 287 (9) - (2012)
Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKC epsilon by Klein, G., Schaefer, A., Hilfiker-Kleiner, D., Oppermann, D., Shukla, P.C., Quint, A., Podewski, E., Hilfiker, A., Schroder, F., Leitges, M., Drexler, H. Circulation Research 15;96 (7) - (2005)
Herceptin, a recombinant humanized anti-ERBB2 monoclonal antibody, induces p53-mediated cardiomyocyte death by Singh* K. K., Shukla* P. C., .. Biochem Biophys Res Commun. 411 421-426 (2011)
DNA damage repair and cardiovascular diseases by Shukla P. C., . .. Canadian Journal of Cardiology 26 13-16 (2010)
Identification of Non-coding RNAs Regulation MLKL/RIPK3 Pathway in Vascular Smooth Muscle Cells: Role of Novel Non-coding RNAs in VSMC Necroptosis ISIRD, SRIC
Area of Research: Basic Cardiovascular Biology
Area of Research: Immune system involvement in cardiac and vascular remodeling