We're working on the areas of cell and molecular biology, medicine and genomics.?
Work is related to long-standing and current problems in:?
- Molecular cardiology and vascular biology: (Key words: heart failure, inflammation & atherosclerosis, apoptosis & novel modes of cell death, cardiac remodeling, regeneration, immunobiology of heart and vessels, non-coding RNAs)?This involves?in vitro?and?in vivo modeling of heart related diseases. With the help of various primary cells and cell lines, genetically modified mice and surgery, we induce diseases & pathologically similar conditions to study cardiovascular problems at cellular level.?
- Developmental biology: (cardiac and vascular development during embryogenesis)?With timed mating protocols and by using genetically modified mice, our focus is to study genes in cardiac development and diseases.
- Pre-clinical and clinical data analysis: Data collection, extraction and analyses of various components of published trials and research outcomes reaching to a fresh perspective and conclusion for an old problem, particularly atherosclerosis.
BRCA1 is an essential regulator of heart function and survival following myocardial infarction by Shukla, P.C*., Singh, K.K*., Quan, A., Al-Omran, M. et. al. Nature Communication 2 - (2011)
Hematopoietic Stem Cell Transcription Factors in Cardiovascular Pathology by Duddu S., Chakrabarti R. , Ghosh A. , Shukla P. C. Frontiers in Genetics 11 - (2020)
Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction by Hilfiker-Kleiner, D., Shukla, P.C., Klein, G., Fischer, P., Schaefer, A., Stapel, B., Hoch, M., Müller, W., Scherr, M.,Theilmeier, G., Ernst, M., Hilfiker, A., Drexler, H. Circulation 122 (2) - (2010)
The forkhead transcription factor Foxo3 negatively regulates natural killer cell function and viral clearance in myocarditis by Loebel M., Luise Holzhauser L. , Hartwig J. A., Shukla P. C., Savvatis K. , Janke A. , Gast M. , Escher F. , Becker S. C., Bauer S. , Stroux A. , Beling A. , Kespohl M. , Pinkert S. , Fechner H. , Kuehl U. , Lassner D. , Poller W. , Schultheiss H. , Zeller T. , Blankenberg S. , Papageorgiou A. , Heymans S. , Landmesser U. , Scheibenbogen C. , Skurk C. European Heart Journal 39 876-887 (2018)
Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 regulate endothelial cell calcium stores and angiogenic function as well as promotes ischemic blood flow recovery by Thompson, M.D., Mei, Y., Weisbrod, R.M., Silver, M., Shukla, P.C., Bolotina, V.M., Cohen, R.A., Tong, X. Journal of Biological Chemistry 289 (29) - (2014)
BRCA1 is a Novel Target to Improve Endothelial Dysfunction and Retard Atherosclerosis by *Singh, K.K., *Shukla, P.C., Quan, A., Al-Omran, M., Lovren, F., Pan, Y., Brezden-Masley, C., Ingram, A.J., Stanford, W.L., Teoh, H., Verma, S. Journal of Thoracic and Cardiovascular Surgery 146 (4) - (2013)
Regulating cardiac energy metabolism and bioenergetics by targeting the DNA damage repair protein BRCA1 by *Singh, K.K., *Shukla, P.C., *Yanagawa, B., Quan, A., Lovren, F, Pan, Y., Wagg, C. S., Teoh, H., Lopaschuk, G. D., Verma, S. Journal of Thoracic and Cardiovascular Surgery 146 (3) - (2013)
BRCA2 deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure by *Singh, K.K., *Shukla, P.C., Quan, A., Desjardins, J-F., Lovren, F., Pan, Y., Garg, V., Gosal, S., Garg, A., Szmitko, P.E., Schneider, M.D., et. al. Journal of Biological Chemistry 287 (9) - (2012)
Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKC epsilon by Klein, G., Schaefer, A., Hilfiker-Kleiner, D., Oppermann, D., Shukla, P.C., Quint, A., Podewski, E., Hilfiker, A., Schroder, F., Leitges, M., Drexler, H. Circulation Research 15;96 (7) - (2005)
Herceptin, a recombinant humanized anti-ERBB2 monoclonal antibody, induces p53-mediated cardiomyocyte death by Singh* K. K., Shukla* P. C., .. Biochem Biophys Res Commun. 411 421-426 (2011)
Identification of Non-coding RNAs Regulation MLKL/RIPK3 Pathway in Vascular Smooth Muscle Cells: Role of Novel Non-coding RNAs in VSMC Necroptosis ISIRD, SRIC
MicroRNA based Reprogramming of Fetal Hemoglobin in Beta-Thalassemia DBT, NEW DELHI
MHC Haplotypes in HBE/Beta Thalassemia: Correlating Disease Heterogeneity and Blood Transfusion Requirements in West Bengal Department of Science and Technology and Biotechnology
Area of Research: Basic Cardiovascular Biology
Area of Research: Immune system involvement in cardiac and vascular remodeling
Area of Research: Cardiovascular pathophysiology
Area of Research: Lung cancer pathogenesis
Area of Research: To study the Bio-Energetic effects of Chanting Sanskrit Mantras