Indian Institute of Technology Kharagpur

Subhas Chandra Kundu

Ph.D.(BHU, Varanasi)

Professor, Biotechnology
S C Kundu joined the Institute in 1994

Contact Addresses

Residence	B-83, IIT Campus, Kharagpur 721302
Phone (office)	+91 - 3222 - 283764
Phone (residence)	+91 - 3222 - 283765 (IIT Phone) +91 - 3222 - 278100 (Private Phone)
email	kundu @ hijli.iitkgp.ernet.in
More Information	http://www.btc.iitkgp.ernet.in/sck.html

Research Areas

Silk biomaterials
Cell based tissue engineering and regenerative medicine

Fellow

The National Academy of Sciences, India

Member of Professional Bodies

Life Member : All India Cell Biology Society
Elected Member, Asia Specific : Tissue Engineering and Regenerative Medicine, International Society

Current Sponsored Projects

Project Title : Immunogenic responses of silk biomaterials used for cell based tissue engineering and regenerative medicine.
Principal Investigator : Dr. S. C Kundu
Co-Principal-Investigators : Dr. A K Ghosh, Dr. T. K. Maiti
Sponsor : Indo Austria, DST
Project Title : Bioinformatics SUB-DIC
Principal Investigator : Prof. S. C. Kundu
Co-Principal-Investigators : Prof. S. Dey
Sponsor : DBT, New Delhi
Project Title : Engineered silk matrices for optimization of in vitro 3-D tumor model
Principal Investigator : Dr. S. C Kundu
Co-Principal-Investigators : Dr. M Mandal
Sponsor : ICMR, New Delhi (sanctioned)
Project Title : Periferal nerve regeneration on silk matrices
Principal Investigator : Professor SC Kundu
Co-Principal-Investigators : Professors AK Ghosh, X. Yang (UK), Z Li (USA)
Sponsor : British Council
Project Title : North Eastern origin silk protein based matrices and nano/microparticles for biomedical applications
Principal Investigator : Professor S. C. Kundu
Co-Principal-Investigators : Dr. Sudip K. Ghosh, BT, IIT, Dr. Dipali Devi, IASST, Guwahati, Dr. L. Rupachandra Singh, Manipur
Sponsor : Department of Biotechnology, New Delhi
Project Title : Silk Protein/Blend Matrices in Tissue Engineering & Biotechnological Applications
Principal Investigator : Professor S. C. Kundu
Co-Principal-Investigators : Professor Sudip K. Ghosh
Sponsor : Department of Science & Technology
Project Title : Indian origin silk based biomimetic scaffolds for engineering of load-bearing tissue
Principal Investigator : Professor S. C. Kundu
Co-Principal-Investigators : Dr. Asok Mukhopadhyay, NII, New Delhi, Dr. M. Mandal SMST
Sponsor : Department of Biotechnology, New Delhi

Member, Editorial Board

Editorial Board Member : Biomaterials
Editorial Board Member : World Journal of Stem Cells
Editorial Board Member : Biomedical Materials
Editorial Board Member : Journal of Biological Engineering
Editorial Board Member : Journal of Regenerative Medicine and Tissue Engineering

Publications: 2012 - 2013

Engineered 3D silk based metastasis models: Interactions between human breast adenocarcinoma, mesenchymal stem cells and osteoblast-like cells by Talukdar S, Kundu SC Advanced Functional Materials, Accepted (2013)
Drug loading and release on tumour cells using silk fibroin- albumin nanoparticles as carriers by Subia B, Kundu SC Nanotechnology, 24 03510 (2013)
The promotion of osseointegration of titanium surfaces by coating with silk protein sericin by Nayak S, Naskar D, Dey T, Kundu SC Biomaterials, 34: 2855-2864 (2013)
Biocompatible composites of fibrous nanohydroxyapatite embedded in a polydimethylsiloxane by Roy N, Dey T, Kundu SC, Bhowmick AK Journal of Materials Science, DOI 10.1007/s10853-0 (2013)
Non-mulberry silk fibroin protein based 3D in vitro tumor model for evaluation of anticancer drug activity by Talukdar S and S. C. Kundu Advanced Functional Materials, 22, 4778-4788 (2012)
Silk sericin/polyacrylamide in situ forming hydrogels for dermal reconstruction by Kundu, B and SC Kundu Biomaterials, 33:7456-7467 (2012)
Natural silk fibroin protein-based transparent bio-memristor. by Hotta, MK, Bera, MK, B. Kundu, S. C. Kundu and C. K. Maiti Advanced Functional Materials, 22, 4493-4499 (2012)
Self-assembly mechanisms of the silk protein sericin on two-dimensional surfaces by Kurland, N. E., J. Kundu, S. Pal, S. C. Kundu, V. K. Yadavalli. Soft Matter, 8 (18), 4952 – 495 (2012)
Silk fibroin biomaterial for tissue regenerations by Kundu B, Rajkhowa R, Kundu SC, Wang X Advanced Drug Delivery Reviews, doi: 10.1016/j.addr. (2012)
Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma by Das S, Dey KK, Dey G, Pal I, Majumder A, MaitiChoudhury S, Kundu SC, Mandal M PLoS ONE, 7 e46641 (2012)

Publications: 2011 - 2012

Self-assembly mechanisms of the silk protein sericin on two-dimensional surfaces. by Kurland, N. E., J. Kundu, S. Pal, S. C. Kundu, V. K. Yadavalli. Soft Matter, Accepted (2012)
Silk fibroin/poly (vinyl alcohol) photocrosslinked hydrogels for delivery of macromolecular drugs. by Kundu J, L A Poole-Warren, P Martens, S.C. Kundu. Acta Biomaterialia, 8:1720-1729 (2012)
Biotechnology of the silk proteins: challenges, approaches and applications. by Nayak, S, N. Bhardwaj, S. Talukdar, B. Kundu, Subia B and S C Kundu. Biotechnology in Biopolymers, Accepted (2012)
Biopolymers: An indispensable tool for biotechnology by Tiwari, A R B. Srivastava, R K. Saini, A K. Bajpai, L H. Innocentini Mei , S.B. Mishra, A. Tiwari, A. Kumar, M. Shahinpoor, G. B. Nando, S. C. Kundu, and Avrath Chadha. Biotechnology in Biopolymers, In press (2012)
The influence of silkworm species on cellular interactions with novel PVA-silk sericin co-hydrogels . by Lim K S., J Kundu, A Reeves, L A. Poole-Warren, S C. Kundu, P J. Martens, Macromolecular Bioscience, 12:322-332 (2012)
Non-mulberry silk biopolymers. by Kundu, S. C, B Kundu, S Talukdar, S Bano, S Nayak, J Kundu, B B. Mandal, N Bhardwaj, M Botlagunta, B C. Dash, C Acharya, and A K. Ghosh. Biopolymers, 97: 455-467 (2012)
Potential of 2D cross-linked sericin membranes with improved biostability for skin tissue engineering. by Nayak, S, S. Talukdar and S. C. Kundu. Cell and Tissue Research: Special issue “Tissue Engineering�?, 347:783-794 (2012)
Silk protein fibroin from Antheraea mylitta for cardiac tissue engineering by Patra, C, S.Talukdar, T. Novoyatleva, S. R. Velagala, C. Mühlfeld, Banani Kundu, S. C. Kundu, and F. B. Engel. Biomaterials, 33:2673-2680 (2012)
Chondrogenic differentiation of rat MSCs on porous scaffolds of silk fibroin/chitosan blends. by Bhardwaj, N and Kundu, SC. Biomaterials, 33:2848-2857 (2012)
Effect of initial cell seeding density on 3D-engineered silk fibroin scaffolds for articular cartilage tissue engineering by Talukdar S, Nguyen QT, Chen AC, Sah RL, Kundu S. C. Biomaterials, 32: 8927-8937 (2011)
Potential of 3-D tissue constructs engineered from bovine chondrocytes / silk fibroin-chitosan for in vitro cartilage tissue engineering. by Bhardwaj N, Nguyen QT, Chen AC, Kaplan DL, Sah RL, Kundu S. C. Biomaterials, 32:5773-5781 (2011)
Freeze-gelled silk fibroin protein scaffolds for potential applications in soft tissue engineering. by Bhardwaj N, Chakraborty S, Kundu S.C. International Journal of Biological Macromolecules, 49: 260-267 (2011)
Silk fibroin protein and chitosan polyelectrolyte complex porous scaffolds for tissue engineering applications by Bhardwaj N and Kundu S. C. Carbohydrate Polymers, 85(2): 325-333 (2011)
Silk protein as biomaterial for tissue engineering and regenerative medicine by Bharadwaj, N, Nayak, S and SC Kundu. Workshop on “New visions for biomaterials and regenerative medicine, March 16-17, 2011 (2011)
Non-mulberry silk sericin/poly (vinyl alcohol) hydrogel matrices for potential biotechnological applications by Mandal B B, Ghosh B, Kundu S. C International Journal of Biological Macrmolecules, 49:125-133 (2011)

Publications: 2010 - 2011

Electrospinning: A fascinating fiber fabrication technique by Bhardwaj N and Kundu SC. Biotechnology Advances, 28:321-347 (2010)
Scaffold fabrication techniques for potential tissue engineering applications. by Subia B, Kundu J, and Kundu SC Tissue Engineering eds., 978-953-307-079-7 (2010)
Osteogenesis of human stem cells in silk biomaterial for regenerative therapy. by Kundu B. and Kundu SC. Progress in Polymer Science, 35:116-27. (2010)
Engineered silk fibroin protein 3-D matrices for in vitro tumor model. by Talukdar S., Mandal M., Hutmacher D. W., Russell P., Soekmadji C., Kundu SC. Biomaterials, 32, 2149-2159 (2011)
Silk fibroin protein and chitosan polyelectrolyte complex porous scaffolds for tissue engineering applications by Bhardwaj N and Kundu SC. Carbohydrate Polymers, doi: 10.1016/j.carbp (2011)
Non-mulberry silk sericin/poly (vinyl alcohol) hydrogel matrices for potential biotechnological applications. by Mandal B B, Ghosh B, Kundu SC. International Journal of Biological Molecules, 49:125-133 (2011)
Implications of surface nanoroughness and RGD sequences on cytoskeleton organization, growth, function of primary rat bone marrow cells by Mandal BB, Das, S, Choudhury, K, Kundu SC. Tissue Engineering Part A, 16 (7):2391-403 (2010)
The fractal self-assembly of the silk protein sericin. by Khire T, Kundu J, Kundu SC, and Yadavalli V. Soft Matter 6:2066-2071., 6:2066-2071. (2010)
Silk fibroin/sodium carboxymethylcellulose blended films for biotechnological applications. by Kundu, J, R. Mahapatra and Kundu SC. Journal of Biomaterials Science: Polymer Edition 22, 519-539, 22, 519-539 (2011)

Publications: 2009 - 2010

Silk fibroin film from non-mulberry tropical tasar silkworms: a novel substrate for in vitro fibroblast culture by Acharya C, Ghosh SK, Kundu SC Acta Biomaterialia, 5, 429-436 (2009)
Characterization of fibroin and PEG blended fibroin matrices for in vitro adhesion and proliferation of osteoblasts. by Acharya C, TV Kumary, S. K Ghosh, Kundu SC Journal of Biomaterial Science, 20: 543-565 (2009)
Silk fibroin/ polyacrylamide semi-interpenetrating network hydrogels for controlled drug release. by Mandal BB, Kapoor S and Kundu SC Biomaterials, 30: 2826-2836 (2009)
Non-bioengineered silk gland fibroin protein micromolded matrices to study cell-surface interactions by Mandal BB, T Das, Kundu SC Journal of Biomaterials Applications, 11: 467-476 (2009)
Cell proliferation and migration in silk fibroin 3D scaffolds by Mandal BB and Kundu SC Biomaterials, 30: 2956-65 (2009)
Silk fibroin/gelatin multilayered films as a model system for controlled drug release. by Mandal BB, Mann JK, Kundu SC European J Pharmaceutical Sciences, 37: 160-171. (2009)
Surface treatment of pure and PEG-4000 blended fibroin films and their characterizations as matrices for in vitro fibroblast culture. by Acharya C, A Dutta, Kundu Journal of Biomaterials Applications, 23 :497-517 (2009)
Osteogenic and adipogenic differentiation of rat bone marrow cells on non-mulberry and mulberry silk gland fibroin 3D scaffolds. by Mandal BB, Kundu SC. Biomaterials, 30: 5019-5030 (2009)
Calcium alginate beads embedded in silk fibroin as 3D dual drug releasing scaffolds. by Mandal BB, Kundu SC Biomaterials, 30:5170-5177 (2009)
Non-mulberry silk gland fibroin protein 3D scaffold for enhanced differentiation of human mesenchymal stem cells into osteocytes. by Mandal BB, Priya AS, Kundu SC Acta Biomaterialia, 5:2575 - 2590 (2009)
Self assembled silk sericin/poloxamer nanoparticles as nanocarriers of hydrophobic and hydrophilic drugs for targeted delivery by Mandal B B and Kundu SC Nanotechnology, 20:355101-15. (2009)
Silk gland sericin protein membranes: Fabrication and characterization for potential biotechnological applications by Dash, B. C., Mandal BB, Kundu SC Journal of Biotechnology, 144:321-329 (2009)
Biospinning by silkworms: Bioengineered silk fiber matrices for tissue engineering applications by Mandal B B and Kundu SC Acta Biomaterialia, 6:360-371 (2010)
Silk fibroin nanoparticles for cellular uptake and control release by Kundu, J Y-II Chung, Y. Ha Kim, G. Tae and Kundu SC International J Pharmaceutics, 388:242-250 (2010)
Biopolymeric nanoparticles by Sundar, S, Kundu, J and Kundu SC Sci. Technol. Adv. Materi, 11:014104-15 (2010)

Publications: 2008 - 2009

Silk sericin protein of tropical tasar silkworm inhibits UVB-induced apoptosis on human skin keratinocyte by Dash R, M. Mandal, SK. Ghosh, Kundu SC Mol Cell Biochem ., 311(1-2) 111-119 (2008)
Non-bioengineered silk gland fibroin protein: characterization and evaluation of matrices for potential tissue engineering applications by Mandal BB, Kundu SC Biotechnology and Bioengineering (Cover page article)., 100 (6) 1237 – 50 (2008)
Silk fibroin protein from mulberry and non-mulberry silkworms: cytotoxicity, biocompatibility and kinetics of L929 murine fibroblast adhesion, by Acharya C, Ghosh SK, Kundu SC J Mater Sci Mater Med., 19 (7) :2827 – 36 (2008)
Mulberry non-engineered silk gland protein vis-à-vis silk cocoon protein engineered by silkworms as biomaterial matrices. by Kundu J., Dewan M., Ghoshal S, Kundu SC Journal of Materials Science: Materials in Medicine, 19 (7) 2679 – 89 (2008)
Natural protective glue protein sericin, bioengineered by silkworms: Potential for biomedical and biotechnological applications by Kundu SC, Dash BC, Dash R, Kaplan DL Progress in Polymer Science, 33, 998-1012 (2008)
Development of Random Amplified Polymorphic DNA Markers for Tropical Tasar Silkworm Antheraea mylitta, by Saha, M. Mahendran, B. Kundu, SC Journal of Economic Entomology, 101(4) 1176-1182 (2008)
Non-bioengineered high strength three-dimensional gland fibroin scaffolds from tropical non-mulberry silkworm for potential tissue engineering applications. by Mandal BB, Kundu SC Macromolecular Bioscience (cover page article), 8, 807-818. (2008)
The effect of lactose-conjugated silk biomaterials on the development of fibrogenic fibroblast by Acharya C, Hinz B, Kundu SC Biomaterials, 29:4665- 4675 (2008)
Design, fabrication and characterization of silk fibroin-HPMC-PEG blended films as a vehicle for transmucosal delivery. by Kundu J, Patra C, Kundu SC Material Science and Engineering C ., 28:1376-1380 (2008)
Novel silk protein sericin gelatin 2D films and 3D scaffolds : Fabrication, characterization and optimization for potential tissue enigneering applications. by Mandal BB, Priya AS, Kundu SC. Acta Biomaterialia, 5:3007-3020 (2009)

Publications: 2007 - 2008

Performance evaluation of a silk protein based matrix for the enzymatic conversion of tyrosine to L-DOPA. by C Acharya, V Kumar, R Sen, S C Kundu Biotechnology Journal, 3, 226-233. (2008)
A novel method for dissolution and stabilization of non-mulberry silk gland protein fibroin using anionic surfactant sodium dodecyl sulfate. by Mandal BB, Kundu SC. Biotechnology and Bioengineering, 99 (6) 1482-1488. (2008)
Antioxidant potential of silk proteins against hydrogen peroxide-induced oxidative stress in skin fibroblasts. by Dash R, Acharya C, Bindu PC and Kundu SC BMB reports, 41(3)236-241. (2008)

Publications: 2006 - 2007

Purification and biochemical characterization of 70 kDa sericin from tropical tasar silkworm Antheraea mylitta. by Rupesh Dash, Sudip K. Ghosh, David L. Kaplan, S. C. Kundu Comparative Biochemistry and Physiology Part-B, 147 (2007) 129-134 (2007)

Publications: 2005 - 2006

Repetitive DNA in tropical tasar silkworm Antheraea mylitta by Mahendran, B., Acharya, C., Dash R., Ghosh, S. K. and Kundu,S. C. Gene 370, 51-57 (2006)
Genetic variation in ecoraces of tropical tasar silkworm,Antheraea mylitta D. using RFLF technique by Mahednran, B., Padhi, B. K., Ghosh, S. K. and Kundu, S. C. Current Science 90, 100-103 (2006)
Molecular phylogeny of silk producing insects based on internal transcribed spacer DNA1 by Mahednran, B.,Ghosh, S. K. and Kundu, S. C. Journal of Biochemistry and Molecular Biology 39, 00-00 (2006)
Molecular Identification of Tropical Tasar Silkworm (Antheraea mylitta) Ecoraces with RAPD and SCAR Markers by Saha. M, Kundu S. C. Biochemical Genetics 44, 72-85 (2006)
Molecular phylogeny of silk producing insects based on 16S ribosomal RNA and cytochrome oxidase subunit 1 genes by Mahednran, B., Ghosh, S. K. and Kundu, S. C. Journal of Genetics 85, 31-38 (2006)
Isolation, purification and characterization of silk protein sericin from cocoon peduncles of tropical tasar silkworm, Antheraea mylitta. by Dash, R., Mukherjee, S., Kundu, S.C. International Journal of Biological Macromolecules 38, 255-258 (2006)
Biological relevance of host plant-derived terpenoid in the cocoons of the tropical tasar silkworm Antheraea mylitta, by P.C. Bindu , P. Jaisankar , F. Hauer, H.O. Gutzeit, S.C. Kundu Biochemical Systematics and Ecology 34, 698-704 (2006)

Some Earlier Publications

Molecular cloning and characterization of Antheraea mylitta cytoplasmic polyhedrosis virus genome segment 9 by K.R. Qanungo, S.C. Kundu, S.C. Mullins, J.I. & A.K. Ghosh Journal of General Virology, 83 PP 1483-1491 (2002)

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