Indian Institute of Technology Kharagpur |

Currently, the "Cell Adhesion Biology Lab" is supported by funding from Department of Biotechnology (DBT), and Indian Council of Medical research (ICMR). | Prospective PhD students (Preferably, M. Tech in Biotechnology/related field OR M.Sc in Biochemistry/Biotechnology/ Microbiology/Molecular Biology) may contact directly to Dr. Samanta (email: dibyendu.samanta@iitkgp.ac.in) | Current Projects: Understanding the molecular mechanism of nectin and cadherin-mediated cell-to-cell adhesion; Role of cadherins and nectins in tumor metastasis; Cadherins in host-pathogen (bacteria) interactions |

Educational Package

Introduction to complex biological systems by De S., Samanta D. - (2025)

Journal

N-terminal ectodomain of BTNL2 inhibits T cell activation via a non-canonical interaction with its putative receptor that results in a delayed progression of DSS-induced ulcerative colitis. by Hansda ., Goswami S. , Mukherjee S. , Basak A. J., Dasgupta S. , Roy P. K., Samanta D. , Mukherjee G. Mol Immunol. 166 39-49 (2024)
In silico and in vitro characterization of the mycobacterial protein Ku to unravel its role in non-homologous end-joining DNA repair by Baral J., Bhattacharje G., Dash S., Samanta D., Hinde E., Rouiller I., Das A.K. International Journal of Biological Macromolecules 278 - (2024)
Molecular Crosstalk Between Adherens Junction Proteins, E-cadherin and Nectin-4 by Dash S., Biswas J., Goswami S., Mukherjee S., Ganguli N., Duraivelan K., Mondal S., Mukhopadhyay R., Samanta D. Journal of Molecular Biology 436 - (2024)
Molecular mimicry of host short linear motif-mediated interactions utilised by viruses for entry by Goswami S., Samanta D., Duraivelan K. Molecular Biology Reports - (2023)
Structural basis of molecular recognition among classical cadherins mediating cell adhesion by Mukherjee S., Goswami S., Dash S., Samanta D. Biochemical Society Transactions - (2023)
Activation and differentiation of cognate T cells by a dextran-based antigen-presenting system for cancer immunotherapy by Mahata D., Mukherjee D. , Biswas D. , Basak S. , Basak A. J., Jamir I. , Pandey N. , Khatoon H. , Samanta D. , Basak A. , Mukherjee G. European Journal of Immunology - (2023)
Molecular and structural basis of TIGIT: Nectin-4 interaction, a recently discovered pathway crucial for cancer immunotherapy by Ganguli N., Kumari P. , Dash S. , Samanta D. Biochem Biophys Res Commun 677 31-37 (2023)
Heterophilic recognition between E-cadherin and N-cadherin relies on same canonical binding interface as required for E-cadherin homodimerization by Dash S., Duraivelan K., Hansda A., Kumari P., Chatterjee S., Mukherjee G., Samanta D. Archives of Biochemistry and Biophysics 727 - (2022)
High-resolution crystal structure of LpqH, an immunomodulatory surface lipoprotein of Mycobacterium tuberculosis reveals a distinct fold and a conserved cleft on its surface by Chatterjee S., Kundapura S.V., Basak A.J., Mukherjee D., Dash S., Ganguli N., Das A.K., Mukherjee G., Samanta D., Ramagopal U.A. International Journal of Biological Macromolecules 210 494-503 (2022)
High-resolution crystal structure of LpqH, an immunomodulatory surface lipoprotein of Mycobacterium tuberculosis reveals a distinct fold and a conserved cleft on its surface by Chatterjee ., Kundapura S. , Basak A. , Mukherjee D. , Dash S. , Ganguli N. , Das A. K., Mukherjee G. , Samanta D. , Ramagopal U. Int J Biol Macromol - (2022)
Cryptic association of B7-2 molecules and its implication for clustering by Lankipalli S., Mahadeva Swamy H.S., Selvam D., Samanta D., Nair D., Ramagopal U.A. Protein Science 30 1958-1973 (2021)
Immunoglobulin-fold containing bacterial adhesins: molecular and structural perspectives in host tissue colonization and infection by Chatterjee S., Basak A. J., Nair A. V., Duraivelan K. , Samanta D. FEMS Microbiol Lett 368 1-14 (2021)
An evolutionarily conserved charged residue dictates the specificity of heterophilic interactions among nectins by Duraivelan K., Dash S. , Samanta D. Biochem Biophys Res Commun 534 504-510 (2021)
Cadherin-mediated host-pathogen interactions by Dash S., Duraivelan K. , Samanta D. Cell Microbiol 23 1-10 (2021)
Emerging roles of the nectin family of cell adhesion molecules in tumour-associated pathways by Duraivelan K., Samanta D. Biochimica et Biophysica Acta - Reviews on Cancer 1876 - (2021)
Tracing the Evolution of Nectin and Nectin-Like Cell Adhesion Molecules by Duraivelan K., Samanta D. Scientific Reports 10 9434-9444 (2020)
Structural Insights into N-terminal IgV Domain of BTNL2, a T Cell Inhibitory Molecule, Suggests a Non-canonical Binding Interface for Its Putative Receptors by Basak A. J., Maiti S. , Hansda A. , Mahata D. , Duraivelan K. , Kundapura . V., Lee . , Mukherjee G. , De S. , Samanta D. Journal of Molecular Biology 432 5938-5950 (2020)
Genetically modified hematopoietic stem/progenitor cells that produce IL-10-secreting regulatory T cells. by Ng S. L., Leno-duran E. , Samanta D. , Almo S. C., Strominger J. L. Proc Natl Acad Sci USA 116(7):2634-2639. 2634-2639 (2019)
Molecular and structural bases of interaction between extracellular domains of nectin-2 and N-cadherin. by Duraivelan K., Basak A. J., Ghosh A. , Samanta D. Proteins 86 1157-1164 (2018)
Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2. by Samanta D., Guo H. , Rubinstein R. , Ramagopal U. , Almo S. Mol Immunol 81 151-159 (2017)
A Possible Role of the Full-Length Nascent Protein in Post-Translational Ribosome Recycling by Das D., Samanta D. , Bhattacharyay A. , Basu A. , Das A. , Ghosh J. , Chakrabarti A. , Dasgupta C. PLoS One 12 e0170-e01703 (2017)
Nectin family of cell-adhesion molecules: structural and molecular aspects of function and specificity by Samanta D., Almo S. Cell Mol Life Sci 72 645-658 (2015)
Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion by Samanta D, Ramagopal UA, Rubinstein R, Vladimir V, Nathenson SG, Almo SC Proc Natl Acad Sci USA 109 14836-14840 (2012)
Identical RNA-protein interactions in vivo and in vitro and a scheme of folding the newly synthesized proteins by ribosomes. by Das D., Samanta D. , Hassan S. , Das A. , Bhattacharyay A. , Dasgupta S. , Chakrabarti A. , Ghorai P. , Dasgupta C. J Biol Chem 287 37508-37521 (2012)
Structural and Functional Characterization of a Single-chain Peptide-MHC Molecule that Modulates Both Naive and Activated CD8+ T Cells by Samanta D*, Mukherjee G*, Ramagopal UA, Chaparro RJ, Nathenson SG, DiLorenzo TP, Almo SC. (*equally contributed) Proc Natl Acad Sci USA 108 13682-13687 (2011)
Mechanism of ribosome assisted protein folding: a new insight into rRNA functions by Samanta D*, Das A, Bhattacharya A, Basu A, Das D, DasGupta C*. (*corresponding author) Biochem Biophys Res Commun 384 137-140 (2009)
In vitro protein folding by E. coli ribosome: unfolded protein splitting 70S to interact with 50S subunit. by Basu A., Samanta D. , Dasgupta C. K. Biochem Biophys Res Commun 366(2) 598-603 (2008)
Protein folding by domain V of Escherichia coli 23S rRNA: specificity of RNA-protein interactions by Samanta D, Mukhopadhyay D, Chowdhury S, Ghosh J, Pal S, Basu A, Bhattacharya A, Das A, Das D, DasGupta C J Bacteriol 190 3344-3352 (2008)
Protein folding following synthesis in vitro and in vivo: association of newly synthesized protein with 50S subunit of E. coli ribosome by Basu A*, Samanta D*, Bhattacharya A, Das A, Das D, Dasgupta C. (*equally contributed) Biochem Biophys Res Commun 366 592-597 (2008)

Congress

E-cadherin and PD-1 interact through their N-terminal ectodomains to inhibit T cell function by Kumari P., Samanta D. , Mukherjee G. 18th International Congress of Immunology, IUIS 2023 - (2023)
The T Cell Inhibitory Molecule Butyrophilin Like-2 Shows Promiscuous Receptor Binding to Regulate Mucosal Immune Response by Hansda A., Basak A. J., Biswas D. , Mahata D. , Samanta D. , Mukherjee G. British Society of Immunology Congress 2021 - (2021)

Conferences

Identification and characterization of novel macromolecular assemblies responsible for cell adhesion by Dash S., Samanta D. ASBMB 2022 Annual Meeting - (2022)
Structural and dynamic investigations of murine BTNL2, an orphan T cell co-inhibitor by Basak A. J., Maiti S. , Hansda A. , Mukherjee G. , De S. , Samanta D. 27th conference of the National Magnetic Resonance Society (NMRS 2022) - (2022)

Symposium

Solution state structural and dynamic studies of mouse BTNL2, an orphan T cell coinhibitory molecule by Basak A. J., Maiti S. , Hansda A. , Mahata D. , Lee W. , Mukherjee G. , De S. , Samanta D. 33rd Annual Symposium of The Protein Society 152-152 (2019)