Rising costs and a depleting supply of oil, as well as environmental concerns, have led to strong interest in renewable fuels and chemicals. In the last decade, there was considerable interest for microbial production of biofuels by metabolic engineering approach as an attractive alternative to transportation fuels.
Recent advancements of synthetic biology have led to the further development of genetic engineering of microorganism, which has been great motivation for developing strategy for microbial production of biofuels. Rational design of metabolism is very important for production of biofuels. In silico prediction of metabolic flux distribution of the metabolic pathways have enabled us to decide the time consuming steps in metabolic engineering.
In recent years significant efforts have been made to engineer microorganisms to produce bioethanol, higher chain alcohols, fatty acids and isoprenoid based biodiesel. Metabolic engineering involves improvement of biofuels formation through the modification of specific genes or addition of new genes involved in biochemical reactions with the use of recombinant DNA technology. System-level approach to analyze and engineer metabolism based on flux distributions obtained from metabolomics and 13C metabolic flux analysis have been extensively used by our group to produce biofuels in Escherichia coli and yeast.
-
Understanding the conformational change and inhibition of hyperthermophilic GH10 xylanase in ionic liquid by Manna B., Ghosh A. Journal of Molecular Liquids 332 115875- (2021)
-
Recent Advances in Systems and Synthetic Biology Approaches for Developing Novel Cell-factories in Non-Conventional Yeasts by Patra P., Das M. , Kundu P. , Ghosh A. Biotechnology Advances 47 107695- (2021)
-
Molecular Insight into glucose induced conformational change to investigate uncompetitive inhibition of GH1 beta-glucosidase by Manna B., Ghosh A. ACS Sustainable Chemistry & Engineering 9 1613-1624 (2021)
-
Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS Cov2 infection by Nanda P., Ghosh A. PLoS Computational Biology 17 e10088- (2021)
-
Understanding the Dissolution of Softwood Lignin in Ionic Liquid and Water Mixed Solvents by Manna B., Ghosh A. International Journal of Biological Macromolecules 182 402-412 (2021)
-
Recent advancements in the ionic liquid mediated lignin valorization for the production of renewable materials and value-added chemicals by Radhakrishnan R., Patra P. , Das M. , Ghosh A. Renewable and Sustainable Energy Reviews 149 111368- (2021)
-
Reconstruction and analysis of genome-scale metabolic model of weak Crabtree positive yeast Lachancea kluyveri by Nanda P., Patra P. , Das M. , Ghosh A. Scientific Reports 10: 16314- (2020)
-
A review on co-culturing of microalgae: A greener strategy towards sustainable biofuels production by Ray A., Nayak M. , Ghosh A. Science of The Total Environment 802 149765- (2022)
-
Solvent Induced Conformational Changes for the Altered Activity of Laccase: A Molecular Dynamics Study by Radhakrishnan R., Manna B. , Ghosh A. Journal of Hazardous Materials 423 127123- (2022)
Principal Investigator
- CRISPR/Ca9 mediated genome engineering in industrially relevant non-conventional yeast Kluyveromyces marxianus for enhanced fatty alcohol production DBT, NEW DELHI
- Deciphering Human Gut Microbial Interactions in Space under Indian Dietary Components KCSTC, ISRO, IIT KHARAGPUR CELL
- IITKGP_SUB MHRD
Co-Principal Investigator
- National Network Project of Department of Biotechnology, IIT Kharagpur Department of Biotechnology
- Understanding Structure Function and Evolution of Regulatory
Networks with a Special Emphasis on Human Diseases-BIC at
Department of Biotechnology, IIT-Kharagpur DBT, NEW DELHI
- Understanding Structure Function and Evolution of Regulatory Networks with a Special Emphasis on Human Diseases-BIC at Department of Biotechnology, IIT-Kharagpur DBT, NEW DELHI
Ph. D. Students
Ayusmita Ray
Area of Research: Metabolic Engineering
Bedashruti Majumdar
Area of Research: Computational Biology
Nidhi Patawari
Area of Research: Metabolic Engineering
P Prasanna
Area of Research: Process and Product Development
Pintu Adak
Area of Research: Microbial Production of Biofuels
R Som Dutt
Area of Research: Microbial Production of Biofules
Ruma Shankaran
Area of Research: Microbial Production of Biofuels
Saswata Dhar
Area of Research: Microbial Production of Biofuels
Sayan Saha Roy
Area of Research: Computer simulation of Bioenergy Systems
Sourav Maity
Area of Research: Bioinformatics and Computational Biology
Suman Mondal
Area of Research: Metagenomics
