I am mainly interested to study biological processes using the tools of statistical mechanics and simulation. I also use analytical and numerical techniques whenever needed. The biological processes that I am mainly interested are closely related to the cell membrane and its mechanics. For example, how do the actin filaments grow and generate force against the cell membrane, how do the cell membrane control and adapt their shape, how different proteins and their conformational changes affect the membrane shape and how the membrane mechanical properties in turn affect the protein mechanics etc. So far, I am only limited to the level of single cell/vesicle, however, cells are often surrounded by other cells, tissues, organs etc. So, in future, I would like to extend my expertise to the multicellular systems. For exapmle, I will be interested to study cell-cell adhesion/interaction, collision between cells, engulfment of cells by another cell, spreading and migration of cell collection etc..
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Conformational Changes of the ABC Transporter BmrA Depend on Membrane Curvature by Damm A., Belhadji K. , Sadhu R. K., Paik S. , Cicco A. D., Manzi J. , Castellana M. , Regmi R. , Margeat E. , Dahan M. , Sens P. , Levy D. , Bassereau P. eLife 15 RP109- (2026)
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The WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation by Wu M., Sadhu R. K., Meyer K. , Tang Z. , Marchando P. , Woolfson D. N., Gov N. S., Weiner O. D. Journal of Cell Biology 224 e202410- (2025)
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A minimal physical model for curvotaxis driven by curved protein complexes at the cell s leading edge by Sadhu R. K., Luciano M. , Xi W. , Torres C. M., Schroder M. , Blum C. , Tarantola M. , Villa S. , Penic S. , Iglic A. , Beta C. , Steinbock O. , Bodenschatz E. , Ladoux B. , Gabriele S. , Gov N. S. Proceedings of the National Academy of Sciences 121 e23068181- (2024)
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Experimental and theoretical model for the origin of coiling of cellular protrusions around fibers by Sadhu R. K., Padilla C. H., Eisenbach Y. E., Penic S. , Zhang L. , Vishwasrao H. D., Behkam B. , Konstantopoulos K. , Shroff H. , Iglic A. , Peles . , Nain A. S., Gov N. S. Nature Communications 14 5612- (2023)
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A minimal cell model for lamellipodia-based cellular dynamics and migration by Sadhu R. K., Iglic A. , Gov N. S. Journal of Cell Sciences 136 jcs260- (2023)
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A theoretical model of efficient phagocytosis driven by curved membrane proteins and active cytoskeleton forces by Sadhu R. K., Barger . R., Penic S. , Iglic A. , Krendel M. , Gauthier N. C., Gov N. S. Soft Matter 19 31-43 (2022)
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Modelling cellular spreading and emergence of motility in the presence of curved membrane proteins and active cytoskeleton forces by Sadhu R. K., Penic S. , Iglic A. , Gov N. S. The European Physical Journal Plus 136 495- (2021)
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Phase diagram of the repulsive Blume Emery Griffiths model in the presence of an external magnetic field on a complete graph by Sadhu R. K., Mukherjee S. , Sumedha S. Journal of Statistical Mechanics: Theory and Experiment 2021 043209- (2021)
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Interplay between surface and bending energy helps membrane protrusion formation by Sadhu R. K., Chatterjee S. Physical Review E (Rapid Comm.) 100 020401- (2019)
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Actin filaments pushing against a barrier: Comparison between two force generation mechanisms by Sadhu R. K., Chatterjee S. European Physical Journal E 42 1-10 (2019)
Principal Investigator
- Coarse Grained Modeling of Multicellular Interaction SRIC, IIT KHARAGPUR
- Coarse Grained Modelling of Collective Cell Migration on Curved Surfaces Anusandhan National Research Foundation (ANRF)
Ph. D. Students
Saswata Kumar Dash
Area of Research: AI and Simulations in Education