IITKGP

Nishant Chakravorty

Associate Professor

School of Medical Science and Technology

nishant@smst.iitkgp.ac.in

Looking for PhD applicants to work on beta-thalassemia related projects. Highly motivated candidates with good academic background are requested to get in touch through email. | Looking for student to work on a project titled "A biomimetic ECM protein-based bioadhesive graft copolymer for implants - Targeting enhanced soft tissue integration and osseointegration". Highly motivated candidates with good academic background are requested to get in touch. | Interested in recruiting new PhD students who are interested to work in the field of beta-thalassemia. Highly motivated candidates with good academic background are requested to get in touch. |

Research Areas

  • Regenerative Medicine
  • Clinical Research
If life is a story, then genetics is its language. Surprisingly, the script for this language, has only four alphabets (A, G, C and T for DNA and A, G, C and U for RNA). This simplicity ingrained in the most complex language of the mortal world has always baffled me as a scientist. I am primarily interested in decrypting the script of life and mastering it modulate health and disease. Decoding the secret language will allow us to develop newer strategies to counter pathophysiological challenges in human beings by encoding and packaging new information in life’s own language. My earlier work involved studying the role of small RNA molecules (known as microRNAs) in the interactions of bone cells with microroughened titanium implant surfaces. Presently I am developing a research lab in the field of regenerative medicine wherein I’ll be using molecular biology tools to study human pathophysiological conditions and attempt to identify therapeutic tools.
  • Comparison of oral dydrogestrone with progesterone gel and micronized progesterone for luteal support in 1,373 women undergoing in vitro fertilization: a randomized clinical study Ashalatha Ganesh, Nishant Chakravorty, Rashmi Mukherjee, Sourendrakanta Goswami, Koel Chaudhury and Baidyanath Chakravarty By Fertility and Sterility 95 (6) 1961-5 (2011)
  • Analyzing microRNA mediated regulation of fetal hemoglobin in beta-thalassemia using miRnalyze, a novel bioinformatics tool Das S. S., James M. , Paul S. , Chakravorty N. By Scientific Devices, Technology Applications & Community Linkage - (2017)
  • Methods in Molecular Biology by Yinghong Zhou, Nishant Chakravorty, Yin Xiao and Wenyi Gu By Mesenchymal stem cells and nano-structured surfaces 133-48 (2013)
  • Alteration of the C-terminal ligand specificity of the Erbin PDZ domain by allosteric mutational effects Javier Murciano-Calles, Megan E. McLaughlin, Ariel Erijman, Yogesh Hooda, Nishant Chakravorty, Jose C. Martinez, Julia M. Shifman and Sachdev S. Sidhu By Journal of Molecular Biology 426 (21) 3500-8 (2014)
  • Pro-osteogenic topographical cues promote early activation of osteoprogenitor differentiation via enhanced TGFβ, Wnt and Notch signaling by Nishant Chakravorty, Stephen Hamlet, Anjali Jaiprakash, Ross Crawford, Adekunle Oloyede, Mohammed Alfarsi, Yin Xiao and Saso Ivanovski By Clinical and Oral Implants Research 25 (4) 475-86 (2014)
  • Lithium release from β-tricalcium phosphate inducing cementogenic and osteogenic differentiation of both hPDLCs and hBMSCs Pingping Han, Mengchi Xu, Jiang Chang, Nishant Chakravorty, Chengtie Wu and Yin Xiao By Biomaterials Science (9) 1230-43 (2014)
  • Computational pharmacokinetics and in vitro-in vivo correlation of anti-diabetic synergistic phyto-composite blend Baishakhi De, Koushik Bhandari, Nishant Chakravorty, Ranjan Mukherjee, Rohit Gundamaraju, Rajeev K Singla, Prakash Katakam, Shanta K Adiki, Biswajoy Ghosh, Analava Mitra By World Journal of Diabetes 6 (11) 1179-85 (2015)

Principal Investigator

  • A Biomimetic ECM Protein-based Bioadhesive Graft Copolymer for Implants - Targeting Enhanced Soft Tissue Integration and Osseointegration MHRD-STARS
  • Mechanistic investigation of the complex inter-relationship between HbE/Beta-thalassemia and protozoan parasite infections with HLA association Indian Council of Medical Research (ICMR)
  • MicroRNA based Reprogramming of Fetal Hemoglobin in Beta-Thalassemia DBT, NEW DELHI
  • SARS-CoV-2 and endothelium: In vitro and in vivo study into pathogenesis of vaccine induced thrombotic thrombocytopenia due to spike protein and vaccine-induced anti- PF-4antibodies and their interactions with endothelium INDIAN COUNCIL OF MEDICAL RESEARCH (ICMR)
  • Vascular remodelling in cancer patients: Role of BRAP gene in the vascular smooth muscle cells after Chemotherapy-associated vascular dysfunction INDIAN COUNCIL OF MEDICAL RESEARCH (ICMR)

Co-Principal Investigator

  • Development of customized implants via powder metallurgy process Science and Engineering Research Board (SERB)
  • Nanoengineered 3D Printed Thinner BRS for Controlled Degradation, Efficient Endothelialization, Antithrombotic, and vSMC-Antiproliferative: An Indigenous Approach to Treat Atherosclerosis (3DNanoResStent) INDIAN COUNCIL OF MEDICAL RESEARCH (ICMR)

Ph. D. Students

Dipanjana Ghosh

Area of Research: Mechanistic insights into Beta-thalassemia and complications

Lopa Mudra Das

Area of Research: Development of a bioadhesive material for medical applications

Mandrita Mukherjee

Area of Research: Genetic modifiers of beta-thalassemia

Motiur Rahaman

Area of Research: New Approaches to Manage Beta-thalassemia

Murali Mohan Mishra

Area of Research: Lipid Nanomaterials

Prasanna Kumar Byram

Area of Research: Tissue Engineering

Shatarupa Bhattacharya

Area of Research: Application of molecular biology approaches for disease management

Sricheta Parui

Area of Research: Human Computer Interaction

Subhangi Basu

Area of Research: Beta-thalassemia and Cardiovascular complications

Surajit Kundu

Area of Research: Medical Image Processing