IITKGP

Research Areas

  • Heart failure and vascular biology
  • Atherosclerosis and non-coding RNAs
  • Immune interaction in heart and vessels
  • Pre-clinical and clinical data analysis
We're working on the cardiovascular biology:

- Molecular cardiology and vascular biology: (Key words: heart failure, inflammation & atherosclerosis, apoptosis & novel modes of cell death, non-coding RNAs) This involves in vitro and in vivo modeling of heart related diseases. With the help of various primary cells and cell lines, genetically modified mice and surgery, we induce diseases & pathologically similar conditions to study cardiovascular problems at cellular level. 
- We are also engaged in cardio-oncology studies, specifically studying the vascular dysfunction in cancer patients related to genotoxic chemotherapy and genetic analysis to identify genes predisposing to increased toxicity.
- Another project aims at studying endothelial dysfunction caused by antibodies that are known to induce thrombotic thrombocytopenia in COVID-19. 
Pre-clinical and clinical data analysis: Meta analysis
 
  • BRCA1 is an essential regulator of heart function and survival following myocardial infarction by Shukla, P.C*., Singh, K.K*., Quan, A., Al-Omran, M. et. al. Nature Communication 2 - (2011)
  • BRCA2 deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure by *Singh, K.K., *Shukla, P.C., Quan, A., Desjardins, J-F., Lovren, F., Pan, Y., Garg, V., Gosal, S., Garg, A., Szmitko, P.E., Schneider, M.D., et. al. Journal of Biological Chemistry 287 (9) - (2012)
  • Natural Killer T cells and the invariant subset promote atherosclerosis: A meta-analysis by Chakrabarti R., Duddu S. , Tiwari A. , Naidu K. , Sharma P. , Chakravorty N. , Shukla P. C. Life Sciences 321 121620- (2023)
  • Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction by Hilfiker-Kleiner, D., Shukla, P.C., Klein, G., Fischer, P., Schaefer, A., Stapel, B., Hoch, M., Müller, W., Scherr, M.,Theilmeier, G., Ernst, M., Hilfiker, A., Drexler, H. Circulation 122 (2) - (2010)
  • The forkhead transcription factor Foxo3 negatively regulates natural killer cell function and viral clearance in myocarditis by Loebel M., Luise Holzhauser L. , Hartwig J. A., Shukla P. C., Savvatis K. , Janke A. , Gast M. , Escher F. , Becker S. C., Bauer S. , Stroux A. , Beling A. , Kespohl M. , Pinkert S. , Fechner H. , Kuehl U. , Lassner D. , Poller W. , Schultheiss H. , Zeller T. , Blankenberg S. , Papageorgiou A. , Heymans S. , Landmesser U. , Scheibenbogen C. , Skurk C. European Heart Journal 39 876-887 (2018)
  • Meta-analysis reveals inhibition of the inflammatory cytokine IL-6 affords limited protection post-myocardial ischemia/infarction by Duddu S., Agrawal M. , Chakrabarti R. , Ghosh A. , Chakravorty N. , Tiwari A. , Shukla P. C. Heliyon 8 1-15 (2022)
  • Inadvertent nucleotide sequence alterations during mutagenesis: highlighting the vulnerabilities in mouse transgenic technology by Ghosh A., Chakrabarti R. , Shukla P. C. J Genet Eng Biotechnol 19 30-41 (2021)
  • Proprotein convertase subtilisin/kexin type 9 (PCSK9): A potential multifaceted player in cancer by Bhattacharya A., Chowdhury A., Chaudhury K., Shukla P.C. Biochimica et biophysica acta. Reviews on cancer 1876 188581- (2021)
  • BRCA1 is a Novel Target to Improve Endothelial Dysfunction and Retard Atherosclerosis by *Singh, K.K., *Shukla, P.C., Quan, A., Al-Omran, M., Lovren, F., Pan, Y., Brezden-Masley, C., Ingram, A.J., Stanford, W.L., Teoh, H., Verma, S. Journal of Thoracic and Cardiovascular Surgery 146 (4) - (2013)
  • Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKC epsilon by Klein, G., Schaefer, A., Hilfiker-Kleiner, D., Oppermann, D., Shukla, P.C., Quint, A., Podewski, E., Hilfiker, A., Schroder, F., Leitges, M., Drexler, H. Circulation Research 15;96 (7) - (2005)

Co-Principal Investigator

  • 4D Cardiac Modelling of Pediatric heart TATA CONSULTANCY SERVICES LIMITED
  • Mechanistic insights on long non-coding RNA (lncRNA)- mediated ceRNA network in fetal hemoglobin regulation Anusandhan National Research Foundation (ANRF)
  • Mechanistic insights on long non-coding RNA (lncRNA)-mediated ceRNA network in fetal hemoglobin regulation Anusandhan National Research Foundation (ANRF)
  • Nanoengineered 3D Printed Thinner BRS for Controlled Degradation, Efficient Endothelialization, Antithrombotic, and vSMC-Antiproliferative: An Indigenous Approach to Treat Atherosclerosis (3DNanoResStent) INDIAN COUNCIL OF MEDICAL RESEARCH (ICMR)

Ph. D. Students

Amitabha Chattopadhyay

Area of Research:

Anindita Bhattacharya

Area of Research: Lung cancer pathogenesis

Gokulmuthu N

Area of Research: To study the Bio-Energetic effects of Chanting Sanskrit Mantras

Rosebin Babu

Area of Research: Nanoformulations for Atherosclerosis

Sammohan Krishna Das

Area of Research: Tissue Engineering

Subhangi Basu

Area of Research: Beta-thalassemia and Cardiovascular complications

Swachhatoa Ghosh

Area of Research: Flexible biomedical sensor