Our Biophysics & Biofluids lab at SMST explores the biophysical principles governing biological and medical systems. Using physics-based modeling, computational fluid dynamics, and data analysis, we study collective cell behaviors and cell and tissue mechanics to drive biomedical innovation. We also leverage artificial intelligence and machine learning to analyze large-scale medical data for improved healthcare solutions.
We investigate how mechanical forces shape cellular and tissue behavior, influencing disease progression, wound healing, cancer invasion, and tissue engineering. By developing physics-based models, we predict tissue morphogenesis, tissue flow, and tumor progression. Additionally, we examine how local microenvironments, such as extracellular matrix properties and mechanical stresses, impact organ development and disease pathology. Through an interdisciplinary approach, our research advances medical science, regenerative medicine, and therapeutic development, contributing to cutting-edge innovations in healthcare.
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Dynamic forces drive cell and organ morphology changes during embryonic development by Manna R. K., Retzlaff E. M., Hinman A. M., Lan Y. , Abdel-razek O. , Bates M. , Hehnly H. , Amack J. D., Manning M. L. Proceedings of the National Academy of Sciences 122 e24181111-e24181111 (2025)
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Dry polymer model for a string of pushers: Nontrivial scaling of tumbling time with shear rate by Saju S.S., Manna R.K., Kumar P.B.S. Physical Review Research 6 - (2024)
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Demixing in binary mixtures with differential diffusivity at high density by Mccarthy E., Manna R. K., Damavandi O. , Manning M. L. Physical Review Letters 132 098301- (2024)
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Multifunctionality of two-dimensional sheets actuated by chemical pumps and motors by Shklyaev O. E., Manna R. K., Balazs A. C. MRS Bulletin 49 1145-1154 (2024)
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Harnessing the power of chemically active sheets in solution by Manna R. K., Laskar A. , Shklyaev O. E., Balazs A. C. Nature Reviews Physics 4 125-137 (2022)
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Chemical pumps and flexible sheets spontaneously form self-regulating oscillators in solution by Manna R. K., Shklyaev O. E., Balazs A. C. Proceedings of the National Academy of Sciences 118 e20229871- (2021)
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Emergent topological phenomena in active polymeric fluids by Manna R. K., Kumar S. P. Soft Matter 15 477-486 (2019)
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Fracture and destratification of three-dimensional multilayered skin epidermis by Manna R. K., Banerjee S. , Burman A. S., Zhang T. , Das T. , Bi D. CompFlu-2024 - (2024)
Principal Investigator
- The role of tissue mechanics in cancer metastasis and bone-scaffold mediated tissue regeneration Sponsored Research and Industrial Consultancy (SRIC)
- Unveiling the role of biomechanical forces in extracellular matrix remodeling during three-dimensional tumor development Anusandhan National Research Foundation (ANRF)
Co-Principal Investigator
- Development of an advanced wound healing patch for microgravity conditions KCSTC, ISRO, IIT KHARAGPUR CELL
Ph. D. Students
Anish Das
Area of Research: Biomaterials
Arkapriya Bhattacharyya
Area of Research: Modeling of infectious Diseases
Krittika Biswas
Area of Research: Active Matter and Biophysics
Payal Panda
Area of Research: Cell adaptation to physicochemical changes
Priyabrata Patra
Area of Research: Tissue mechanics
Tushar Das
Area of Research: Predictive Mathematical Modeling
