BioMEMS is a rapidly advancing, inter-disciplinary research field for creation and development of new methods/systems to effectively process or manipulate biological materials with electronic devices and components. Giving a prior importance to the biomedical sensing research, an interdisciplinary R&D work at School of Medical Science and Technology, IIT Kharagpur has been initiated to promote MEMS and Biosensor activity that encompasses design, fabrication and engineering of biomedical & microfluidic devices for its electro-physiological characterisation. For the evaluation of electrical and physical properties of biomolecules and cells using suitable micro-fluidic devices, appropriate fabrication of polymeric coated bio-MEMS are being investigated and its utility are evaluated under different microscopic and electrical impedance study. The research also involves development of different BioMEMS transducers and related technologies for sensing various biomedical signals for precise and appropriate diagnostics and therapeutics. Microfabrication technology is being explored to develop various miniature MEMS devices for deployment of in-vivo and in-vitro detection of biomedical signals and its characterisation.
Presently, the following activities are being pursued:
- Development of MEMS based flow sensor on flexible substrate - Realization of a polymer (PDMS) based cardiovascular shear stress/ flow sensor using micro fabrication techniques on catheter to monitor real-time blood flow for atherosclerosis diagnosis satisfying sensitivity, biocompatibility and reliability requirements. The major aim of this research is to develop catheter-based MEMS sensors to provide high spatial and temporal resolution for real-time monitoring in the vasculature.
Separation and manipulation of cells on Microfluidic Platform by Dielectrophoresis - Realization of an integrated microfluidic device with planer electrodes for rapid and continuous separation of biological cells in mixed cell population with high selectivity using dielectrophoresis technique.
MEMS based Biosensor for Electrophysiological characterization of cells – Electrical impedance spectroscopy (EIS) is used to study the electrochemical phenomena in cells and the toxicological effects in cells.
-
Fibril growth captured by electrical properties of amyloid-beta and human islet amyloid polypeptide by Awasthi P., Singh A. , Khatun S. , Gupta A. N., Das S. Physical Review E 101 062413- (2020)
-
In vivo performance analysis of silanized and coated nitinol wires in biological environment by Sinha S., Priyadarshani J. , Devi K. B., Kishore A. V., Das P. , Chanda A. , Das S. , Roy M. , Nandi S. K. Journal of Materials Research 35 1262-1270 (2020)
-
Mapping of biomechanical properties of cell lines on altered matrix stiffness using Atomic Force Microscopy by Wala J., Das S. Biomechanics and Modeling in Mechanobiology - (2020)
-
Cost-effective fabrication of ionic polymer based artificial muscles for catheter-guidewire maneuvering application by Tripathi A. S., Chattopadhyay B. P., Das S. Microsystem Technologies 25 1129-1134 (2019)
-
Conducting Polymers for Biomedical Imaging by Kulkarni G., Dixit K. , Parimi J. L., Bora H. , Saha B. , Das S. , Dhara S. Conducting Polymers Chemistries, Properties and Biomedical Applications 207-222 (2022)
-
Hydrogel microbeads including agarose microbeads and a process for preparing the same by Priyadarshani J., Chakraborty S. , Das S. - (2022)
Principal Investigator
- DEVELOPMENT OF A PAPER BASED IMPEDIMETRIC SENSOR FOR RAPID AND QUANTITATIVE ASSESSMENT OF pH, UREA AND CREATININE IN BLOOD INDIAN COUNCIL OF MEDICAL RESEARCH (ICMR)
- Machine Learning Driven Smartphone App Interfaced Paper-Based Point-of-Care Diagnostic for Comprehensive Detection of Iron Deficiency Anemia by Image Processing Indian Council of Medical Research, Dept. of Health Research, Ministry of Health and Family Welfare
Co-Principal Investigator
- Centre of excellence for training and research in Microfluidics IIT KHARAGPUR
- Developing Human Bone mimetic 3D Bio-printed Organoid Models for Drug / Toxicology Screening: Characterizing it with Advanced Imaging Scheme for Promotion of Academic and Research Collaboration (SPARC), Apex Committee of SPARC, Ministry of Education
- Development of a multiplexed autoantibody detection device and identification of autoreactive CD8+ T cell specificities in Type 1 Diabetes patients in India INDIAN COUNCIL OF MEDICAL RESEARCH (ICMR)
- Label-Free Detection Of Circulating Exhausted CD8+ T
Cells Using Raman Spectroscopy In Murine Models Of
Metastatic And Non-Metastatic Cancer Science and Engineering Research Board (SERB)
- Label-Free Detection Of Circulating Exhausted CD8+ T Cells Using Raman Spectroscopy In Murine Models Of Metastatic And Non-Metastatic Cancer Anusandhan National Research Foundation (ANRF)
- Large-Scale Fabrication of OFET-Based Temperature and Humidity Sensors for Smart Spirometer Integration Ministry of Electronics and Information Technology
- SMST Facility User Charges Various internal users of the Institute
Ph. D. Students
Abesh Barman
Area of Research: Microfluidics and point of care device
Akashlina Tarunkanti Basu
Area of Research: Flexible biomedical sensor
Aparajita Pati
Area of Research: Infectious Diseases and microfluidics
Asmita Das
Area of Research: Cancer Biology
Biswadeep Roy
Area of Research: Microfluidics
Camellia Mitra
Area of Research: Biomicrofluidics
Koushik Jana
Area of Research: Biosensor and Point of Care Device for Health Care Application
Payal Panda
Area of Research: Cell adaptation to physicochemical changes
Pooja C Asani
Area of Research: Development of a multiplexed autoantibody sensor for Type 1 Diabetes diagnostics
Pratyusa Mohapatra
Area of Research: nanobiosensor
Shreya Das
Area of Research: nanomaterial based Microdevices for cancer detection
Smriti Sinha
Area of Research: Biosensors and biomicrofluidics
Subhobrata Banerjee
Area of Research: Biomedical Sensor
Swachhatoa Ghosh
Area of Research: Flexible biomedical sensor