Bridging Clinical Chemistry, Diagnostics and Basic Research in Age-Related Diseases
Our research group operates at the intersection of clinical chemistry diagnostics and basic research, with a specific focus on age-related diseases. We delve into both clinical and basic research domains to understand the underlying cellular changes associated with aging, as well as age-related diseases such as sarcopenia, Alzheimer's disease, and Parkinson's disease.
Age-related diseases are complex and multifactorial, and our research aims to explore the intricate connections between various factors that contribute to their development. We specifically investigate mitochondrial defects, oxidative stress, and inflammatory stress, which are considered the main driving forces behind age-related diseases. By understanding these mechanisms, we aim to identify potential therapeutic targets and develop strategies for their attenuation.
A key area of interest in our lab is the exploration of mitochondrial structural, functional, and genetic defects in different diseases. Mitochondria play a crucial role in cellular energy production and the regulation of metabolic and physiological processes. Defects in mitochondria can disrupt these processes, leading to functional impairments and ultimately contributing to the development of diseases. We strive to identify and characterize these defects, with the ultimate goal of developing interventions to reverse or mitigate their effects.
Our research combines clinical insights and laboratory techniques to gain a comprehensive understanding of age-related diseases. Through collaborations with clinicians, researchers, and industry professionals, we aim to translate our findings into clinical applications and diagnostic tools. By bridging the gap between basic research and clinical practice, we seek to improve disease management, develop personalized therapeutic approaches, and ultimately enhance the quality of life for individuals affected by age-related diseases.
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-Synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: implications in the pathogenesis of Parkinson's disease Bir A., Sen O. By Journal of Neurochemistry 131 868-877 (2014)
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Multiple mechanisms of age-dependent accumulation of amyloid beta protein in rat brain: Prevention by dietary supplementation with N-acetylcysteine, -lipoic acid and -tocopherol Sinha M., Bir A. By Neurochemistry International 95 92-99 (2016)
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Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer's Disease. Chakrabarti S., Bir A. By Current Alzheimers Research 13 1232-1248 (2016)
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Role of written examination in the assessment of attitude ethics and communication in medical students: Perceptions of medical faculties. Ghosh A., Bir A. By Journal of Education and Health Promotion 10 10-23 (2021)
Principal Investigator
- Molecular analysis of the role of myocyte derived cytokines (myokines) in pathogenesis of age-related sarcopenia. SRIC, IIT KHARAGPUR
