Biomolecular EPR Spectroscopy Lab:
My research focuses on the field of electron paramagnetic resonance (EPR) spectroscopy, with an emphasis on elucidating biomolecular structures, dynamics, and reactivity. Using advanced EPR spectroscopic techniques, including continuous wave (CW) EPR, double electron-electron resonance (DEER), and hyperfine spectroscopic techniques such as electron nuclear double resonance (ENDOR) and electron-electron double resonance (ELDOR)-detected NMR (EDNMR), my group aims to address fundamental questions to unraveling the mysteries of disordered proteins associated with human diseases. Additionally, we investigate the structure-function relationships of metalloproteins and their reactive intermediates, contributing to a deeper understanding of biological processes at the molecular level.
If you have a background either in protein biochemistry or spectroscopy, and are interested in working with EPR spectroscopy (project, PhD and postdoc), please drop me an email manasseal@edu.iitkgp.ac.in
Admission to the Ph.D. Programme for the Autumn Semester 2025-26 at IIT Kharagpur is open now. Department of Education, IIT Kharagpur, is currently offering Ph.D. in Chemistry, Physics, and Education. Please visit the Ph.D. Admission Notice @ https://www.iitkgp.ac.in/phd-admission
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Core-shell model of the clusters of CPEB4 isoforms preceding liquid-liquid phase separation by Oranges M., Jash C. , Golani G. , Seal M. , Cohen S. R., Rosenhek-goldian I. , Bogdanov A. , Safran S. , Goldfarb D. Biophysical Journal - (2024)
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Extending the Range of Distances Accessible by 19F Electron Nuclear Double Resonance in Proteins Using High-Spin Gd(III) Labels by Bogdanov A., Frydman V. , Seal M. , Rapitsky L. , Schnegg A. , Zhu W. , Iron M. , Gronenborn A. M., Goldfarb D. Journal of the American Chemical Society 146 6157-6167 (2023)
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GdIII 19F Distance Measurements for Proteins in Cells by Electron Nuclear Double Resonance by Seal M., Zhu W. , Dalaloyan A. , Feintuch A. , Bogdanov A. , Frydman V. , Su . , Gronenborn A. M., Goldfarb D. Angewandte Chemie International Edition 62 e2022187- (2023)
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Peptide-RNA coacervates as a cradle for the evolution of folded domains by Seal M., Weil-ktorza O. , Despotovic D. , Tawfik D. S., Levy Y. , Metanis N. , Longo L. M., Goldfarb D. Journal of the American Chemical Society 144 14150-14160 (2022)
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Evolution of CPEB4 dynamics across its liquid liquid phase separation transition by Seal M., Jash C. , Jacob R. S., Feintuch A. , Harel Y. S., Albeck S. , Unger T. , Goldfarb D. Journal of Physical Chemistry B 125 12947-12957 (2021)
- Co-Principal Investigator
