A fundamental challenge in cell biology is to understand how biochemical reactions are organized and precisely regulated in space and time in the densely packed cellular microenvironment. One way cells achieve this specificity is by compartmentalization of the cellular space into subcellular compartments. Besides the classical membrane bound organelles such as the nucleus, mitochondria, endoplasmic reticulum, there exists a repertoire of membraneless organelles including nucleolus, stress granules, germ granules and others, which are now considered to be biomolecular condensates.

My lab is interested in studying the molecular principles of assembly, function and regulation of membraneless RNA-protein condensates primarily using the fruit fly germline development model.

Key research questions include:
- Translation regulation in ribonucleoprotein (RNP) granules
- Compositional control of biomolecular condensates
- Role of RNA-RNA interactions in scaffolding RNP granule assembly
- Regulation of functional material properties of condensates

All Publications

Target-dependent biogenesis of cognate microRNAs in vitro by Bose M., Bhattacharyya S. N. MicroRNA Protocols 27-29 (2018)
An architectural role of specific RNA-RNA interactions in oskar granules by Bose M., Rankovic B. , Mahamid J. , Ephrussi A. Nature Cell Biology 26 1934-1942 (2024)
Liquid-to-solid phase transition of oskar ribonucleoprotein granules is essential for their function in Drosophila embryonic development by Bose M., Lampe M. , Mahamid J. , Ephrussi A. Cell 185 1308-1324 (2022)
Retrograde trafficking of Argonaute 2 acts as a rate-limiting step for de novo miRNP formation on endoplasmic reticulum attached polysomes in mammalian cells by Bose M., Chatterjee S. , Chakrabarty Y. , Barman B. , Bhattacharyya S. N. Life Science Alliance 3 - (2020)
Spatiotemporal uncoupling of microRNA-mediated translational repression and target RNA degradation controls microRNP recycling in mammalian cells by Bose M., Barman B. , Goswami A. , Bhattacharyya S. Molecular and Cellular Biology 37 e0046-16 (2017)
Target-dependent biogenesis of cognate microRNAs in human cellsTarget-dependent biogenesis of cognate microRNAs in human cells by Bose M., Bhattacharyya S. N. Nature Communications 7 - (2016)

Completed Projects

Principal Investigator

Generating functional specificity in condensates that are crucial for Drosophila germline development SRIC, IIT KHARAGPUR
Investigating the molecular principles of two dimensional phase separation on cellular membranes Anusandhan National Research Foundation (ANRF)
Role of cytoskeleton in the assembly of ribonucleoprotein granules by two-dimensional phase separation in the Drosophila germline Department of Science and Technology (DST)
Role of cytoskeleton in the assembly of ribonucleoprotein granules by two-dimensional phase separation in the Drosophila germline Department of Science and Technology

Alumni members