Major interest of my laboratory is to understand the molecular mechanism of pathogenesis of autism and autism spectrum disorders. Currently, are using biochemical, cell biological and genetic and optogenetic approaches to understand the physiological function of a specific protein called Ube3a and how its gain as well as loss of function is linked with autism and autism spectrum disorders. We are also screening pharmacological inducers of Ube3a, which might be useful in the therapy of learning and memory disorders.
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Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease by Tanaka M., Machida Y. , Niu S. , Ikeda T. , Jana N. R., Doi H. , Kuroshawa M. , Nekooki M. , Nukina N. Nature Medicine 10 148-151 (2004)
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Prenatal exposure of azadiradione leads to developmental disabilities by Jana S., Das S. , Giri B. , Archak R. , Bandyopadhyay S. , Jana N. R. Molecular Neurobiology - (2024)
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Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release by Jana N. R., Zemskov E. A., Wang G. , Nukina N. Human Molecular Genetics 10 1049-1059 (2001)
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Dexamethasone induces heat shock response and slows down disease progression in mouse and fly models of Huntington s disease. by Maheshwari M., Bhutani S. , Das A. , Mukherjee R. , Sharma A. , Kino Y. , Nukina N. , Jana N. R. Human Molecular Genetics 23 2737-2751 (2014)
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Deficiency of Ube3a in Huntington's disease mice brain increases aggregate load and accelerates disease pathology by Maheshwari M., Shekhar S. , Singh B. K., Jamal I. , Vatsa N. , Kumar V. , Sharma A. , Jana N. R. Human Molecular Genetics 23 6235-6245 (2014)
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Ube3a deficiency inhibits amyloid plaque formation in APPswe/PS1 E9 mouse model of Alzheimer s disease by Singh B. K., Vatsa N. , Kumar V. , Sekhar S. , Sharma A. , Jana N. R. Human Molecular Genetics 26 4042-4054 (2017)
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Topoisomerase inhibitor topotecan delays the disease progression in a mouse model of Huntington s disease by Shekhar S., Vatsa N. , Kumar V. , Singh B. K., Jamal I. , Sharma A. , Jana N. R. Human Molecular Genetics 26 420-429 (2017)
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Azadiradione restores protein quality control and ameliorates the disease pathogenesis in a mouse model of Huntington s disease by Singh B. K., Vatsa N. , Nelson V. K., Kumar V. , Kumar S. S., Mandal S. C., Pal M. , Jana N. R. Molecular Neurobiology 55 6337-6346 (2018)
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Withaferin A Induces Heat Shock Response and Ameliorates Disease Progression in a Mouse Model of Huntington s Disease by Joshi T., Kumar V. , Kaznacheyeva E. , Jana N. R. Molecular Neurobiology - (2021)
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Simvastatin restores HDAC1/2 activity and improves behavioural deficits in Angelman syndrome model mouse by Kumar V., Joshi T. , Vatsa N. , Singh B. K., Jana N. R. Frontiers in Molecular Neuroscience 12 1-11 (2019)
Principal Investigator
- Institute Small Animal House IIT KHARAGPUR
Ph. D. Students
Amiyangshu De
Area of Research: Neurobiology
Ann Soniya M Micheal
Area of Research: Auditory Neural Processing
Bhaskarjyoti Giri
Area of Research: Neuroscience
Sagarika Das
Area of Research: Neuroscience
