My present research interest lies in understanding the role of specific nutrients like vitamin in immune system. We would determine how the nutrients affect the adaptive immune system by regulating the development of T helper cells. T helper cells play important role in protecting us from various pathogens by producing cytokines. However, if unregulated the immune responses generated by T helper cells can cause various inflammatory disorders. Based on the cytokines in the microenvironment and produced and the expression of transcription factors, T helper cells have been classified into distinct subsets. Among different vitamins, role of vitamin A and vitamin D have been explored in the differentiation of certain T helper cells. In addition, the function of these vitamins have also been explored in disease models like allergic asthma and experimental autoimmune encephalomyelitis. We would like to define how vitamin A and D regulate the development of various T helper cells including IL-9-producing Th9 cells. Th9 cells play important role in the development of asthma, exacerbate ulcerative colitis; while they aid in the expulsion of helminthic infection and antitumor activity in mouse model of melanoma. Thus, delineating the role of vitamin A and vitamin D in regulating the differentiation of Th9 cells will aid us developing future therapeutics. We would like to build a network of inflammatory diseases whereby IL-9 play key role.

We are also intersted in understanding the role of the Hox family of transcription factors in the differentiation of T helper cells.

All Publications

Calcitriol and Retinoic acid antagonize each other to suppress the production of IL-9 by Th9 cells by Vyas S. P., Goswami R. Journal of Nutritional Biochemistry - (2021)
17- estradiol signalling affects cardiovascular and cancer pathogenesis by regulating the crosstalk between transcription factors and EC-miRNAs by Hansda A.K., Goswami R. Gene Reports 24 - (2021)
Share Calcitriol Impairs the Secretion of IL-4 and IL-13 in Th2 Cells via Modulating the VDR-Gata3-Gfi1 Axis by Biswas B., Chattopadhyay S. , Hazra S. , Goswami R. Journal of Immunology 831-842 (2024)
Calcitriol Regulates the Differentiation of IL-9-Secreting Th9 Cells by Modulating the Transcription Factor PU.1 by Vyas S. P., Hansda A. K., Kaplan M. H., Goswami R. Journal of Immunology 204 1201-1213 (2020)
Differential Gene Expression Analysis in 1,25(OH)2D3 treated Human Monocytes establishes link between AIDS Progression, Neurodegenerative disorders, and Aging by Biswas B., Goswami R. Meta Gene - (2021)
Rheumatoid Arthritis: melting pot of T helper subsets by Vyas S. P., Hansda A. K., Goswami R. International Reviews of Immunology 212-231 (2019)
17- Estradiol (E2) distinctly regulates the expression of IL-4 and IL-13 in Th2 cells via modulating the interplay between GATA3 and PU.1. by Goswami R., Hansda A. K., Biswas B. Cytokine 173 - (2024)
Calcitriol attenuates TLR2/IL-33 signaling pathway to repress Th9 cell differentiation and potentially limits the pathophysiology of Rheumatoid Arthritis by Vyas S. P., Srivastava R. N., Goswami R. Molecular and Cellular Biochemistry 476 369-384 (2021)
Interleukin-10 to Interleukin-6 Ratio in Swab Samples act as Decisive Hyper-Inflammatory Indicators for all Patients potentially infected with the SARS-CoV-2 Delta Variant by Biswas B., Roy S. , Banerjee I. , Jana S. , Bhattacharjee B. , Chakraborty S. , Mondal A. , Goswami R. Heliyon 16985-16985 (2023)
COVID-19 pandemic: the delta variant, T-cell responses, and the efficacy of developing vaccines by Biswas B., Chattopadhyay S., Hazra S., Hansda A.K., Goswami R. Inflammation Research 71 377-396 (2022)

Completed Projects

Principal Investigator

Differential expression of Follicular fluid Fatty acids in women with polycystic ovaries: correlation with successful pregnancy outcome INDIAN COUNCIL OF MEDICAL RESEARCH (ICMR)
Functional characterization of intestinal macrophages in CD4 T cell regulation in colorectal diseases by short-chain fatty acids as gut microbial metabolites DEPARTMENT OF BIOTECHNOLOGY
Investigating HOXB4-MEIS1/PBX1 and HOXB4-non-TALE interactions in Asthma: Uncovering Novel Transcriptional Axes in Allergic Inflammation Anusandhan National Research Foundation (ANRF)