Bioscience and Biotechnology

• Ramalingaswamy Fellowship 2015
• EMBO Long term fellowship 2009
• INSA Young Scientist 2011
• DBT-CTEP travel award

Patent
• Unilamellar liposomal formulation of Norclomipramine for treatment of Visceral Leishmaniasis by Bosedasgupta S., Das P. , Roy S. - (2025)
• SPECIALIZED SINGLE STRANDED OLIGONUCLEOTIDE PROBES FOR RAPID DETECTION OF RIFAMPICIN-RESISTANT TUBERCULOSIS (RR-TB) by Bosedasgupta S., Sankhla A. - (2024)
• Host-targeted, surface functionalized, Immunomodulatory nanovesicle formulation against Tuberculosis by Bosedasgupta S., Roy S. , Roy S. - (2024)
Journal
• Novel cationic bolaamphiphiles for in vitro gene delivery and antibacterial properties by Mondal P., Roy S., Dey J., Dasgupta S.B. Journal of Drug Delivery Science and Technology 106 - (2025)
• S-nitrosylation-triggered secretion of mycobacterial PknG leads to phosphorylation of SODD to prevent apoptosis of infected macrophages by Saha S., Roy S., Hazra A., Das D., Kumar V., Singh A.K., Singh A.V., Mondal R., Dasgupta S.B. Proceedings of the National Academy of Sciences of the United States of America 122 - (2025)
• Resolving the polycistronic aftermath: Essential role of topoisomerase IA in preventing R-loops in Leishmania by Das P., Hazra A. , Saha S. , Roy S. , Mukherjee M. , Majumder H. K., Bosedasgupta S. Journal of Biological Chemistry 300 107162-107180 (2024)
• Impact of Linker Groups on Self-Assembly, Gene Transfection, Antibacterial Activity, and In Vitro Cytotoxicity of Cationic Bolaamphiphiles by Mondal P., Roy S. , Dey J. , Bosedasgupta S. ACS Appl. Bio Mater. 7 1703-1712 (2024)
• Impact of the Hydrocarbon Chain Length of Biodegradable Ester-Bonded Cationic Gemini Surfactants on Self-Assembly, In Vitro Gene Transfection, Cytotoxicity, and Antimicrobial Activity by Dahal H., Roy S. , Dey J. , Bosedasgupta S. Langmuir 40 2242-2253 (2024)
• Gelatin-decorated Graphene oxide: A nanocarrier for delivering pH-responsive drug for improving therapeutic efficacy against atherosclerotic plaque by Yadav S. K., Das S. , Linkon A. , Saha S. , Bosedasgupta S. , Ray S. K., Das S. International Journal of Pharmaceutics - (2024)
• Self-Assembly, In Vitro Gene Transfection, and Antimicrobial Activity of Biodegradable Cationic Bolaamphiphiles by Mondal P., Dey J. , Roy S. , Bosedasgupta S. Langmuir 39 10021-10032 (2023)
• Genome-wide identification of CAMTA gene family members in rice (Oryza sativa L.) and in silico study on their versatility in respect to gene expression and promoter structure. by Banerjee J., Bosedasgupta S. Functional & Integrative gGnomics 22 193-214 (2022)
• A bumpy ride of Mycobacterial Phagosome maturation: roleplay of Coronin1 through Cofilin1 and cAMP by Saha S., Hazra A. , Ghatak D. , Singh A. V., Roy S. , Bosedasgupta S. Frontiers in Immunology 12 - (2021)
• ESX secretion system: the gatekeepers of mycobacterial survivability and pathogenesis by Roy S., Ghatak D. , Bosedasgupta S. European Journal of Microbiology and Immunology 10 202-209 (2020)
• The ultimate fate determinants of drug induced cell-death mechanisms in Trypanosomatids by Das P., Saha S. , Bosedasgupta S. Int J Parasitol Drugs Drug Resist. 15 81-91 (2020)
• It takes two to tango : role of neglected macrophage manipulators Coronin 1 and Protein kinase G in mycobacterial pathogenesis by Saha S., Das P. , Bosedasgupta S. Frontiers Cellular and Infection Microbiology 10 582563- (2020)
• Macrophage-microbe interaction: lessons learned from the pathogen Mycobacterium tuberculosis. by Bosedasgupta S., Pieters J. Seminars in Immunopathology 40 577-591 (2018)
• Activation of the cAMP/protein kinase A signalling pathway by coronin 1 is regulated by cyclin-dependent kinase 5 activity. by Liu X*, BoseDasgupta S*, Jayachandran R, Studer V, Rühl S, Stiess M, Pieters J.(*contributed equally) FEBS Journal 590(2) 279-87 (2016)
• Cytokine-Induced Macropinocytosis in Macrophages is regulated by 14-3-3ζ through its Interaction with Serine-Phosphorylated Coronin. (Journal Cover and Editors Choice Article with Podcast) by BoseDasgupta S and Pieters J FEBS Journal 282(7) 1167-81 (2015)
• Coronin 1 regulates cognition and behavior through modulation of cAMP/protein kinase A signaling. by Jayachandran R*, Liu X*, BoseDasgupta S*, Mueller P*, Zhang LC, Genoud JS, Fossoud C, Gambino F., Khelfaoui M, Steiss M, Luthi A., Humeau Y and Pieters J (*contributed equally)) PLoS Biology 12(3) - (2014)
• Coronin 1 trimerization is essential to protect mycobacteria within macrophages from lysosomal delivery by BoseDasgupta S and Pieters J. FEBS Letters 588(21) 3898-905 (2014)
• Striking the Right Balance Determines TB or Not TB. by BoseDasgupta S, Pieters J. Frontiers in Immunology 5 - (2014)
• Inflammatory stimuli reprogram Macrophage phagocytosis to macropinocytosis for the rapid elimination of pathogens. (Journal Cover Article)) by BoseDasgupta S and Pieters J PLoS Pathogens 10(4) - (2014)
• Activated group 3 innate lymphoid cells promote T- cell mediated immune responses. by Vonburg N., Bosedasgupta S. , Pieters J. , Finke D. PNAS 111 12835-40 (2014)
• Antigen Processing and T cell Activation by Dendritic cells is Independent of Coronin 1 by Westritschnig K., Bosedasgupta S. , Pieters J. Mol. Immunology 53 379-86 (2013)
• Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis. by Jayachandran R., Bosedasgupta S. , Pieters J. Curr. Top. Microbiol. Immunol - (2012)
• Cryptolepine-Induced Cell Death of Leishmania donovani Promastigotes Is Augmented by Inhibition of Autophagy by Sengupta S., Bosedasgupta S. Mol Biol Int. 187850- (2011)
• ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism by Sengupta S., Bosedasgupta S. Nucleic Acids Research 39 3295-309 (2011)
• Topoisomerase I gene mutations at F270 in the large subunit and N184 in the small subunit contribute to the resistance mechanism of the unicellular parasite Leishmania donovani towards 3,3'-diindolylmethane. by Roy A., Bosedasgupta S. Antimicrobial Agents & Chemotherapy 53 2589-98 (2009)
• Mutational studies reveal lysine 352 on the large subunit is indispensable for catalytic activity of bi-subunit topoisomerase I from Leishmania donovani by Ganguly A., Bosedasgupta S. Mol Biochem Parasitol 165 57-66 (2009)
• Amino acids 39-456 of large subunit and 210-262 of small subunit constitute the minimal, functionally interacting fragments of the unusual heterodimeric topoisomerase IB of Leishmania by BoseDasgupta S, Das BB, Sengupta S, Ganguly A, Roy A., Tripathi G and Majumder HK Biochemical Journal 409 481-9 (2008)
• An insight into the mechanism of inhibition of unusual bi-subunit topoisomerase I from Leishmania donovani by 3,3'-diindolylmethane, a novel DNA topoisomerase I poison with a strong binding affinity to enzyme. by Roy A., Bosedasgupta S. Biochem J 409 611-622 (2008)
• A novel ATP binding cassette transporter, ABCG6 is involved in chemoresistance of Leishmania by Bosedasgupta S., . Molecular Biochemical Parasitology 158(2) 176-88 (2008)
• The caspase-independent algorithm of programmed cell death in Leishmania induced by baicalein: the role of LdEndoG, LdFLAP1 and LdTatD by BoseDasgupta S, Das BB, Sengupta S, Roy A, Ganguly A, Tripathi G and Majumder HK Cell Death & Differentiation 15(10) 1629-40 (2008)
• The large subunit of Leishmania topoisomerase I functions as the molecular steer in type IB topoisomerase. by BoseDasgupta S., Ganguly A., Das BB., Roy A., Khalkho NVM. and Majumder HK Molecular Microbiology 67 31-46 (2008)
• Mitochondria- dependent reactive oxygen species mediated programmed cell death induced by 3,3'-diindolylmethane through inhibition of F0F1-ATP synthase in unicellular protozoan parasite Leishmania donovani by Roy A., Bosedasgupta S. Molecular Pharmacology 75 1292-1307 (2008)
• Leishmania donovani bisubunit topoisomerase I gene fusion leads to an active enzyme with conserved type IB enzyme function by Das B. B., Bosedasgupta S. FEBS J 274 150-163 (2007)
• Betulinic acid, a catalytic inhibitor of topoisomerase I inhibits ROS mediated apoptotic topo I-DNA cleavable complex formation in prostate cancer cells but does not affect the process of cell death. by Ganguly A., Bosedasgupta S. Cancer Research 11848-11858 (2007)
• Differential induction of Leishmania donovani bi-subunit topoisomerase I-DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I. by Das B. B., Bosedasgupta S. Nucleic Acids Research 1121-1134 (2006)
• 'LeishMan' topoisomerase I: an ideal chimera for unraveling the role of the small subunit of unusual bi subunit topoisomerase I from Leishmania donovani. by Ganguly A., Bosedasgupta S. Nucleic Acids Research 34 6286-6297 (2006)
• N-terminal region of thelarge subunit of Leishmania donovani bi-subunit topoisomerase I is involved in DNA relaxation and interaction with the smaller subunit. by Das B., Bosedasgupta S. Journal of Biological Chemistry 280 16335-16344 (2005)
Workshop
• Hindering the dance to death: Mycobacteria secreted PknGmediated phosphorylation of macrophage PSMD9, preventsmacrophage apoptosis through activation of NF-kB andrepression of TNFa by Saha S., Das P. , Dasgupta A. , Bosedasgupta S. Cell Death in Immunity and Inflammation 32-33 (2019)
• Host-directed immunomodulatory therapeutics against tuberculosis by Dasgupta S. B. Biosafety and Biosecurity in Biomedical Laboratories - (2018)
• Identifying the host substrates of the secreted mycobacterial virulence factor PknG by Dasgupta S. B. Regional Young Investigators Meeting - (2018)

Principal Investigator

• Elucidating SOCS1 and CISH Mediated Dampening of IFNg Signalling During Mycobacterial Pathogenesis using Genome Editing Technologies
• Understanding the Metabolic Adoptation Leading to Chemoresistance in Leishmania Against Novel Drugs that Target Unique Prokaryotic TopA Homolog
• Delineating the Molecular Intercome of Calcineurin, Post Phagosome Formation in Mycobacterial Pathogenesis
• Identifying the Host Substrates for the Mycobacterial Virulence Factor Protein Kinase G, its Functional Characterization in Context of Mycobacterial Survival
• HIT-TB: Host Targeted Immunomodulatory Therapy for Tuberculosis using Bi-functional Pro-drug Constituted, Drug Loaded, Surface Functionalized Nanocapsules
• Elucidating the Mechanism of S-nitrosylation of Mycobacteria Secreted Protein Kinase G (PknG) and its Consequent Phosphorylation of Macrophage Suppressor of Death Domain (SODD) in Hindering Macrophage Apoptosis
• Elucidating the Mechanism of S-nitrosylation of Mycobacteria Secreted Protein Kinase G (PknG) and its Consequent Phosphorylation of Macrophage Suppressor of Death Domain (SODD) in Hindering Macrophage Apoptosis
• Delineating the mechanism of anti-leishmanial activity of Tricyclic antidepressant Norclomipramine for drug repurposing studies
• Delineating the mechanism of anti-leishmanial activity of Tricyclic antidepressant Norclomipramine for drug repurposing studies
• Host-directed Therapy against Tuberculosis using Vitamin D Constituted Surface Functionalized Nanocapsiles Loaded with Immunomodulatory Drug