Our present research involves design and synthesis of new, well-defined smart architectural polymers (block, graft, bottle-brush, star, core cross-linked star, nanogels) aimed mainly towards targeted drug/gene delivery applications, by application of latest organic transformation techniques along with controlled radical polymerization strategies. Development of different polyelectrolyte systems and their interaction studies with surfactants, proteins and nucleic acids have also been part of our research interest. We are also interested in the synthesis of various hydrogels and study their swelling behavior. Our research contribution also includes development of novel functionalized and polymer-coated nanoparticles that have proved effective as targeted drug-delivery agents.
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Bicontinuous Nanoparticles from Spontaneous Self-Assembly of Block Copolymer Prodrug in Aqueous Medium for Potential Cancer Therapy by Pal J., Samanta P., Khan A., Maity R., Mallick A.I., Dhara D. ACS Macro Letters 14 26-34 (2025)
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Thermal and pH Responsive Polymer-Tethered Multifunctional Magnetic Nanoparticles for Targeted Delivery of Anti-cancer Drug by B. Sahoo, K. S. P. Devi , R. Banerjee, T. K. Maiti, P. Pramanik, D. Dhara* ACS Applied Materials and Interfaces 5 - (2013)
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Effect of Polymer Chain Length, pH, and Temperature on the Preparation of Polymer-Gold Nanoconjugates and Their Application in Catalysis by Bera S., Padhee J., Pal J., Dhara D. ACS Applied Polymer Materials 7 3368-3377 (2025)
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Raspberry-like gold nano-conjugates of block copolymer prodrug based bicontinuous nanoparticles for cancer theranostics by Pal J., Khan A., Samanta P., Khamrai M., Mallick A.I., Dhara D. Journal of Colloid and Interface Science 687 817-829 (2025)
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Stimuli-Responsive Polymer Stabilized Iron Oxide Nanoparticle as Green Catalyst for Styrene Oxidation Reaction by Bera S., Pal J. , Sahoo S. , Dhara D. ACS Applied Polymer Materials 5 720-730 (2023)
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Histidine-based reduction-sensitive star-polymer inclusion complex as a potential DNA carrier: Biophysical studies using time-resolved fluorescence as an important tool by Sahoo S., Bera S., Dhara D. Langmuir 36 11262-11273 (2020)
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A copper-free click reaction for the synthesis of redox-responsive water-soluble core cross-linked nanoparticles for drug delivery in cancer therapy by Biswas G., Jena B.C., Sahoo S., Samanta P., Mandal M., Dhara D. Green Chemistry 21 5624-5638 (2019)
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Redox-Responsive Core-Cross-Linked Block Copolymer Micelles for Overcoming Multidrug Resistance in Cancer Cells by Maiti C., Parida S. , Kayal S. , Maiti S. , Mandal M. , Dhara D. ACS Applied Materials and Interfaces 10 5318-5330 (2018)
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Energy-Transfer Phenomena in Thermoresponsive and pH Switchable Fluorescent Diblock Copolymer Vesicles by Maiti C., Dhara D. Langmuir 33 12130-12139 (2017)
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Thermoregulated Formation and Disintegration of Cationic Block Copolymer Vesicles: Fluorescence Resonance Energy Transfer Study by C. Maiti, D. Dey, S. Mandal, and D. Dhara* The Journal of Physical Chemistry B 118 - (2014)
Principal Investigator
- Tumor Microenvironment Responsive Size-Tunable Multi Therapeutic Nanosystems with Multimodal Imaging Capability Anusandhan National Research Foundation (ANRF)
- Tumor Microenvironment Responsive Size-Tunable Multi-Therapeutic Nanosystems with Multimodal Imaging Capability for Improved Diagnosis Science and Engineering Research Board (SERB)
Co-Principal Investigator
- Advancing Breast Cancer Chemo-and Immunotherapy using stimuli-responsive nanoparticle Indian Council of Medical Research, Dept. of Health Research, Ministry of Health and Family Welfare
Ph. D. Students
Apala Jana
Area of Research: Polymer Chemistry
Jitu Padhee
Area of Research: Polymer Science
Manisha Khamrai
Area of Research: Polymer Chemistry
Prithwish Kola
Area of Research: Cancer Biology
Rishabh Maity
Area of Research: Polymer Chemistry
Suchismita Pradhan
Area of Research: Biophysical Chemistry
Trisha Kaushik
Area of Research: Polymer Science