IITKGP
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Chemistry

Faculty

Rambabu Reddi, IIT Kharagpur

Rambabu Reddi

Assistant Professor Grade-I

Chemistry

+91-3222-283314

rambabu@chem.iitkgp.ac.in

Awards and Accolades

Personal Webpage Bio Sketch

Research Areas

  • Organic -, Bioorganic - Medicinal Chem.
  • Organic synthesis
  • Cancer Drug Discovery
  • Biochemistry
  • Chemical Biology
  • 1. Development of novel covalent inhibitors for protein targets in cancer and neurodegenerative diseases.
    2. Design new electrophilic warheads to enhance the potency and selectivity of covalent inhibitors.
    3. Novel chemistry techniques for chemical biology applications, such as proteomics, activity-based protein profiling (ABPP),
        turn-on fluorescent probes, prodrugs, cellular labeling with small molecule probes, live cell imaging, protein degradation kinetics,
        high-throughput screening assay development, and covalent docking.
    4. Development of novel small molecule degraders, including molecular glues and PROTACs.
All Publications
  • Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry by Reddi R. J. Am. Chem. Soc. 145 3346-3360 (2023)
  • Site-Specific Labelling of Endogenous Proteins Using CoLDR Chemistry by Reddi R. J. Am. Chem. Soc. 143 20095-20108 (2021)
  • Tunable Methacrylamides for Covalent Ligand Directed Release Chemistry by Reddi R. J. Am. Chem. Soc., 143 4979-4992 (2021)
Completed Projects

Principal Investigator

  • Affinity-guided enzymatic reactions for efficient drug discovery SRIC, IIT KHARAGPUR
  • Deciphering the catalytic behavior of therapeutic proteins for targeted drug delivery Anusandhan National Research Foundation (ANRF)
  • Development of Allosteric Interactors of GIRK channels derived from Ethosuximide Department of Science and Technology (DST)
Alumni members

Ph. D. Students

Humpi Boppuri

Area of Research: Medicinal chemistry of covalent inhibitors

Megha Tyagi

Area of Research: Nitrogen electrophiles in covalent inhibitor design

Srikrishna Khamrai

Area of Research: Deciphering the catalytic behavior of therapeutic proteins for targeted drug delivery

Subhabrat Panda

Area of Research: Medicinal chemistry of covalent inhibitors

Teegala Vikas

Area of Research: Deciphering the catalytic behavior of therapeutic proteins for targeted drug delivery

Trishnita Bhowmick

Area of Research: Deciphering the catalytic behavior of therapeutic proteins for targeted drug delivery