We are looking for highly motivated PhD students interested in transition metal catalysis, C-H bond functionalizations and asymmetric synthesis for coming Autumn semester. For more details visit https://www.rsamanta.com |

Research Areas

Synthetic Organic Chemistry
Transition Metal Catalysis
Asymmetric Synthesis

“The ideal synthesis creates a complex skeleton..in a sequence only of successive construction reactions involving no intermediary. Refunctionalization, and leading directly to the structure of the target, not only its skeleton but also its correctly placed functionality.”[Hendrickson, J. B. J. Am. Chem. Soc. 1975, 97, 5784.] The outlook of synthetic organic chemistry is changing very rapidly. But one feature is still unique to all molecular architects i.e. the ability to design and development of new molecules. Basically, the pathways to achieve the targets are changing in synthetic organic chemistry. The challenges posed by pharmaceutical, biology and material science seek attention from synthetic chemist to provide faster, economic and environmentally acceptable solutions. Catalysis, especially transition metal catalysis has taken a lead role to provide architecturally complex molecules in more faster, milder and simpler way. We are involved in developing new transition metal catalysed synthetic technology and late stage functionalization of complex molecules. We are using these protocols to make strategies that enable the rapid formation of library of complex, unprecedented structure which can be further examined for unexplored biological properties. Another field of interest is to furnish the complete architecture of biologically active natural products using inert bond activation strategy.

All Publications

Cu(II)-Catalyzed Construction of Heterobiaryls using 1-Diazonaphthoquinones: A General Strategy for the Synthesis of QUINOX and Related P,N Ligands by Biswas A., Pan S., Samanta R. Organic Letters 24 1631-1636 (2022)
Copper Catalyzed Regioselective Cascade Alkylation and Cyclocondensation of Quinoline N-Oxides with Diazo esters: Direct Access to conjugated -Systems by Biswas A., Karmakar U. , Pal A. , Samanta* R. Chem A Eur J 22 13826-13830 (2016)
Rh(III)-Catalyzed Weakly Coordinating 2-Pyridone-Directed Oxidative Annulation Using Internal Alkynes: A Reversal in Selectivity by Bera S., Sarkar S., Pal J., Samanta R. Organic Letters 24 8470-8475 (2022)
Weakly Coordinating tert-Amide Assisted Ru(II)-Catalyzed Synthesis of Azacoumestans via Migratory Insertion of Quinoid Carbene: Application in Total Synthesis of Isolamellarins by Sarkar S., Samanta R. Organic Letters 24 4536-4541 (2022)
Iridium(III)-Catalyzed Intermolecular Mild N-Arylation of Aliphatic Amides Using Quinoid Carbene: A Migratory Insertion-Based Approach by Bera S., Roy S., Pal S.C., Anoop A., Samanta R. ACS Catalysis 11 10847-10854 (2021)
Rh(iii)-Catalyzed mild straightforward synthesis of quinoline-braced cyclophane macrocycles: Via migratory insertion by Ghosh B., Bera S., Ghosh P., Samanta R. Chemical Communications 57 13134-13137 (2021)
Rh(iii)-Catalyzed tandem indole C4-arylamination/annulation with anthranils: Access to indoloquinolines and their application in photophysical studies by Biswas A., Bera S., Poddar P., Dhara D., Samanta R. Chemical Communications 56 1440-1443 (2020)
Rh(iii)-Catalyzed straightforward arylation of 8-methyl/formylquinolines using diazo compounds by Ghosh B., Samanta R. Chemical Communications 55 6886-6889 (2019)
Direct Pd(II)-Catalyzed Site-Selective C5-Arylation of 2-Pyridone Using Aryl Iodides by Maity S., Das D. , Sarkar S. , Samanta* R. Organic Letters 20 5167-5171 (2018)
Regiocontrolled Direct C4 and C2-Methyl Thiolation of Indoles under Rhodium Catalyzed Mild Conditions by Maity S., Karmakar U. , Samanta* R. Chem. Commun. 53 12197-12200 (2017)

Completed Projects

Principal Investigator

Migratory Insertion Based Direct Step-economic Arylations using Quinone Diazides: Applications in the Synthesis of C3-Arylated Pyrroloindolines, Intramolecular N-Arylation and Synthesis of Natural Products Council of Scientific and Industrial Research
Migratory Insertion Based Direct Step-economic Arylations using Quinone Diazides: Applications in the Synthesis of C3-Arylated Pyrroloindolines, Intramolecular N-Arylation and Synthesis of Natural Products Council of Scientific and Industrial Research, Extramural Research Division
Strategies for Macrocycles and Related Chiral Macrocycles using Metal Carbenes: Applications in Ligands and Natural Products Anusandhan National Research Foundation (ANRF)
Synthesis of Bis(indole) Alkaloid Arundanine and Related Scaffolds using Site-Selective Direct Aryl-Amination Strategy Anusandhan National Research Foundation (ANRF)

Alumni members