IITKGP

Research Areas

  • Asymmetric Synthesis
  • Total Synthesis of Natural Products
  • Biocatalysis in Organic synthesis
Total synthesis of natural products is the most challenging and intriguing area of research in the chemical science related disciplines. In the early 20th century, the field of synthetic organic chemistry, while established in many respects, was to continue a sharp path of progress and advancement for over a century to reach the level of power and sophistication that it possesses today. This is a unique tool for accessing new chemical entities with great biological potential, which seems to be impossible to access from natural sources due to its scarce availability. In our group we focus on the total synthesis of structurally and architecturally complex natural products. The selection of our target molecules is mainly based on strategy driven approach.
  • Stereoselective desymmetrization of 2,2-bishydroxymethyl-1-tetralones by iodocyclization, synthesis of novel [6,6,5] tricyclic framework and chemo- enzymatic diversity generation by T. Mahapatra, N. Jana and S. Nanda Adv. Syn. Catal 353 2152-2168 (2011)
  • Asymmetric total synthesis of (-)-rasfonin by R. Bhuniya and S. Nanda Tetrahedron 69 1153-1165 (2013)
  • Enantiomeric scaffolding of α-tetralone and related scaffolds by EKR (enzymatic kinetic resolution) and stereoselective ketoreduction with ketoreductases by R. Bhuniya, T. Mahapatra and S. Nanda Org. Biomol. Chem 10 536-547 (2012)
  • Asymmetric total synthesis of paecilomyci E, 10-epi-paecilomycin E and 6-epi-cochliomycin C by P. Pal, N. Jana and S. Nanda Org. Biomol. Chem 12 8257-8274 (2014)
  • Chemoenzymatic asymmetric total synthesis of nonanolide (Z)-cytospolides D,E and their stereoisomers by R. Rej and S. Nanda Eur. J. Org. Chem 860-871 (2014)
  • Klebsiella pneumoniae (NBRC 3319) Mediated Asymmetric Reduction ofα-Substituted β-Oxo Esters and Its Application to the Enantioiselective Synthesis of Small-Ring Carbocycle Derivatives by R. Bhuniya, T. Mahapatra and S. Nanda Eur. J. Org. Chem 1597-1602 (2012)
  • Asymmetric synthesis of cochliomycin-A and zeaenol by N. Jana and S. Nanda Eur. J. Org. Chem 4313-4320 (2012)
  • Stereoselecive synthesis of enantiopure oxetanes, carbohydrate mimic, ε-lactone, and cyclitols from biocatalytically derived β-hydroxyesters as chiral precursors by D. Das, J. Halder, R. Bhuniya and S. Nanda Eur. J. Org. Chem 5229-5246 (2014)
  • Asymmetric synthesis of naturally occurring (-)-seimatopolides A and B by R. Rej, P. Pal and S. Nanda Tetrahedron 70 4457-4470 (2014)
  • Asymmetric synthesis of naturally occurring nonenolide xyolide through cross metathesis and macrolactonization reaction by R. Rej, A. Jana and S. Nanda Tetrahedron 70 2634-2642 (2014)

Principal Investigator

  • Asymmetric total synthesis of naturally occurring [5,5]-oxaspirolactone containing bergamotane sesquiterpenes: New class of anti-diabetic and anti-obesity agents Anusandhan National Research Foundation (ANRF)
  • Design, synthesis and evaluation of new and efficient ligands for the separation of the targeted actinide ions from nuclear waste BRNS, DAE, MUMBAI

Ph. D. Students

Anupa Karmakar

Area of Research: Asymmetric Total synthesis of Complex Natural products

Chandan Kumar Soni

Area of Research: Asymmetric total synthesis of complex natural products

Debarghya Sau

Area of Research: Asymmetric Total synthesis of Complex Natural products

Jayanta Das

Area of Research: Asymmetric total synthesis of diterpenoid natural products

Rajarshee Sarkar

Area of Research: Total synthesis of butenolides and related naturall pproducts

Santu Bisui

Area of Research: Asymmetric total synthesis of complex natural products

Saubhik Ghosh

Area of Research: Asymmetric total synthesis of diterpenoid natural products

Suman Bhatta

Area of Research: Asymmetric total synthesis of complex natural products

Swagata Das

Area of Research: Asymmetric total synthesis of complex natural products