Development of catalytic & asymmetric 1,2-migration of boronate esters for alkene/alkyne functionalization; a new direction in asymmetric synthesis:

We have been interested in developing asymmetric multicomponent coupling reactions to functionalize olefin and alkyne. Asymmetric di-functionalization of olefin, adding two distinct functional groups on each side of the C-C bond, in a single operation is one of the most attractive transformations in organic chemistry. Sharpless di-hydroxylation & amino-hydroxylation; Jacobsen epoxidation and ring opening; are the benchmark reactions for asymmetric functionalization of the alkene. In recent years, few catalytic and asymmetric palladium/copper/rhodium catalyzed alkene functionalization was reported. While some of these reactions are limited to activated alkene or offer narrow functional group tolerance. We are interested in asymmetric, catalytic functionalization of alkene using 1,2-boronate rearrangements

Total synthesis of spiroketal based natural products having cytotoxicity against cancer cell lines

All Publications

Palladium Catalyzed Asymmetric Three Component Coupling of Boronic Esters, Indoles and Allylic Acetates by Panda S., Ready J. Journal of American Chemical Society 139 6038-6041 (2017)
Synthesis and Utility of Dihydropyridine Boronic Esters by Panda S., Coffin A. , Nguyen Q. , Tantillo P. , Ready P. Angew. Chem. Int. Ed. 55 2205-2209 (2016)
Synthesis of a potential intermediate for TMC-95A via an organocatalyzed aldol reaction by Panda S., Pearson A. , Bunge S. Journal of Organic Chemistry 78 9921-9928 (2013)
N-prolinylanthranilamide pseudopeptides as bifunctional organocatalysts for asymmetric aldol reactions by Panda S., Pearson A. Organic Letters 13 5548-5551 (2011)
N-Prolinylanthranilic Acid Derivatives as Bifunctional Organocatalysts for Asymmetric Aldol Reactions by Panda S., Pearson A. Tetrahedron 67 3969-3975 (2011)
Tandem Allylation/1,2-Boronate Rearrangement for the Asymmetric Synthesis of Indolines with Adjacent Quaternary Stereocenters by Panda S., Ready J. J. Am. Chem. Soc 140 13242-13252 (2018)
Transition Metal Free Synthesis of Heterobiaryls through 1,2 Migration of Boronate Complex by Panda S., Paul S. , Das K. K., Manna S. Chemistry A European Journal 26 1922-1927 (2020)
Functionalization of Heterocycles Through 1,2 Metallate Rearrangement of Boron Ate Complex by Panda S., Das K. K. Chemistry An European Journal - (2020)

Completed Projects

Principal Investigator

Catalytic and enantioselective strain release driven ring opening of azabicyclobutane ring to access diversely substituted azetidines Anusandhan National Research Foundation (ANRF)

Alumni members