IITKGP
Narayan Dhuleep Pradeep Singh, IIT Kharagpur

Narayan Dhuleep Pradeep Singh

Professor

Chemistry

+91-3222-282324

ndpradeep@chem.iitkgp.ac.in

Research Areas

  • Design and Development of FPRPG.
  • Development of One and Two-Photon PRPG.
  • PRPG for release of Gasotransmitters.
  • Photocatalysis for Organic Synthesis.

Our research group works at the interface of chemistry, biology and material sciences with light as an important tool. We are interested in designing new fluorescent Photoremovable Protecting groups for controlled release of bioactive molecules. Recent research in our laboratory has focused on the following areas: 

Controlled Drug delivery:

Real time monitoring Single component nano vehicle for image guided drug delivery

Di & Tri modal Combination Therapy

Micro environment assisted real time monitoring based drug delivery

    Photocatalysis for Organic transformations

    Organic Reactive intermediates

    Self assembled Smart Materials

    • Photocaging of Single and Dual (Similar or Different) Carboxylic and Amino Acids by Acetyl Carbazole and its Application as Dual Drug Delivery in Cancer Therapy by Pradeep N. D., Mandal M. , Venkatesh Y. , Rajesh Y. , Karthik D. , Chetan A. C., Jana D. journal of organic chemistry 81 11168-11175 (2016)
    • Wavelength-Selective Xanthene-Based Monochromophoric Photoremovable Protecting Groups for Tuning Soft Matter Material Properties by Mondal S., Koay W.L., Daga I., Paul S., Truong V.X., Singh N.D.P. Journal of the American Chemical Society 146 23376-23386 (2024)
    • Exploring Excited-State Intramolecular Proton-Coupled Electron Transfer in Dinuclear Ir(III)-Complex via Covalently Tagged Hydroquinone: Phototherapy Through Futile Redox Cycling by Shee M., Schleisiek J., Maity N., Das G., Montesdeoca N., Ha-Thi M.-H., Gore K.R., Karges J., Singh N.D.P. Small 20 24084- (2024)
    • Riboflavin-Induced DNA Damage and Anticancer Activity in Breast Cancer Cells under Visible Light: A TD-DFT and In Vitro Study by Majumder R., Banerjee S., Paul S., Mondal S., Mandal M., Ghosh P., Maity D., Anoop A., Singh N.D.P., Mandal M. Journal of Chemical Information and Modeling 64 5580-5589 (2024)
    • Light Switchable Bioorthogonal Reaction Manifold for Modulation of Hydrogel Properties by Koay W.L., Gao C., Vu Q.T., Oh X.Y., Lin H., Mondal S., Singh N.D.P., Loh X.J., Le M.T.N., Truong V.X. Biomacromolecules 25 6635-6644 (2024)
    • Visible Light-Triggered Single-Component Photocage Nanoparticles for Combinatorial Photodynamic Therapy and Chemotherapy by Ray S., Roy P.K., Singh N.D.P. ACS Applied Nano Materials 8 3020-3028 (2025)

    Principal Investigator

    • One- and Two-Photon Responsive Photo Acid Generators (PAGs) and Their Application for Functional Group Photolithography Science and Engineering Research Board (SERB)
    • Wavelength Selective Tuning of Local pH A Strategy for Modulating Amyloid Fibrillogenesis and Defibrillogenesis Anusandhan National Research Foundation (ANRF)
    • wavelength-selective Photochemical Modulation of Local pH for Spatiotemporal Control of Amyloid Fibrillogenesis in Alzheimer Disease Anusandhan National Research Foundation (ANRF)

    Co-Principal Investigator

    • Design and Development of Autonomic Repairing and Mechano-responsive Smart Elastomers Defence R and D Organization (HQ) Armament Research Board

    Ph. D. Students

    Malabika Bera

    Area of Research: organic Photochemistry

    Sayan Paul

    Area of Research: Computational Chemistry

    Soumik Chatterjee

    Area of Research: Organic photochemistry

    Subham Pal

    Area of Research: organic Photochemistry

    Suchhanda Biswas

    Area of Research: organic Photochemistry

    Sukla Garain

    Area of Research: Organic Photochemistry

    Swapnamoy Sahoo

    Area of Research: Organic Photochemistry

    Syaleena Parveen

    Area of Research: Organic Photochemistry