IITKGP

Research Areas

  • Theoretical Biophysics
  • Active Matter
  • Statistical Physics
  • Image and Data Analysis
We are a computational physics group driven by a deep curiosity about physics inspired from biological systems. We leverage theoretical and numerical methods from statistical physics, dynamical systems, and computer science to study collective dynamics in living systems. Through our research, we aim to bridge the gap between theoretical predictions and real-world observations, ultimately contributing to a deeper understanding of the physics of life. We work on the following specific reasearch areas.

Active Matter: Active Matter refers broadly to collectives of physical and biological systems, ranging from groups of migrating cells and swarms of birds to animals that convert internal energy into active motion at the individual level. We are interested in understanding the role of deformability, intrinsic heterogeneity, and surface adhesion in biological collective behavior using multi-scale simulations of active particles.

Population Dynamics: Microbial population dynamics is dictated by single-cell growth, which is determined by underlying genetic networks and cell-cell physical interactions. We aim to develop a multi-scale simulation framework that integrates the dynamics of gene regulatory networks and cell mechanics, driven by physical collisions, to study the surface morphology and spatial expansion of bacterial colonies formed by different types of bacteria.

AI & Data Science: Recent advances in experimental and high-resolution microscopy have provided us with unprecedented details of cell shape, mechanics, and cell-cell interaction mechanisms during various biological processes. However, interpreting such large volumes of data requires the development of data analysis tools that can characterize the data into low-dimensional measures as well as help us develop better theoretical models. We are particularly interested in developing novel algorithms for motion and shape tracking, spatial clustering, image correlations, and distance measurements to characterize experimental datasets.

For internships, projects, collaborations, and opportunities in our new research group, please don't hesitate to reach out to us.
  • Collective migration reveals mechanical flexibility of malaria parasites by Patra P., Beyer K. , Jaiswal A. , Battista A. , Rohr K. , Frischknecht F. , Schwarz U. S. Nature Physics 586-594 (2022)
  • Mechanism of kin-discriminatory demarcation line formation between colonies of swarming bacteria by Patra P., Vassallo C. N., Wall D. , Igoshin O. A. Biophysical Journal 2477-2486 (2017)
  • Colony expansion of socially motile Myxococcus xanthus cells is driven by growth, motility, and exopolysaccharide production by Patra P., Kisson K. , Cornejo I. , Kaplan H. B., Igoshin O. A. PLoS Computational Biology e10050- (2016)
  • Phenotypically heterogeneous populations in spatially heterogeneous environments by Patra P., Klumpp S. Physical Review E (Rapid Communications) 030702- (2014)
  • Emergence of phenotype switching through continuous and discontinuous evolutionary transitions by Patra P., Klumpp S. Physical biology 046004- (2012)
  • Contact Dynamics of Cytoadhering Plasmodium falciparum-Infected Erythrocytes in Flow by Scholz K., Papagrigorakes M., Lettermann L., Pennarola F., Patra P., Dasanna A.K., Sanchez C.P., Kehrer J., Cavalcanti-Adam E.A., Schwarz U.S., Tanaka M., Lanzer M. ACS Infectious Diseases 11 2628-2643 (2025)
  • Fano Factor as the Key Measure of Sensitivity in Biological Networks by Banerjee K., Patra P., Kolomeisky A.B., Das B. Journal of Physical Chemistry Letters 16 10174-10179 (2025)
  • Pair cross-correlation analysis for assessing protein co-localization by Patra P., Sanchez C.P., Lanzer M., Schwarz U.S. Biophysical Journal - (2025)

Principal Investigator

  • Investigating the role of shape and heterogeneity in active matter using agent-based simulations. SRIC, IIT KHARAGPUR

Ph. D. Students

Aindrila Deb

Area of Research: Active Matter and Theoretical Biophysics

Ankush Semwal

Area of Research: Active Matter and Theoretical Biophysics

Anubhab Makhal

Area of Research: Biophysics

Rajib Mahato

Area of Research: Active Matter and Theoretical Biophysics